In vitro inhibition of vasopressin release in brain by behaviorally relevant ethanol concentrations

Roberta E. Brinton; Raphael Gruener; Pushpa Deshmukh; Henry I. Yamamura

doi:10.1016/0304-3940(86)90400-3

In vitro inhibition of vasopressin release in brain by behaviorally relevant ethanol concentrations

Roberta E. Brinton, Raphael Gruener, Pushpa Deshmukh, Henry I. Yamamura

Pharmacology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We have investigated the effect of ethanol upon vasopressin (AVP) content in brain and upon in-vitro release of AVP from the rat median eminence. In-vitro ethanol concentrations (5-25 mM), comparable to behaviorally relevant blood ethanol levels, induce a substantial inhibition of AVP release from the median eminence, whereas higher ethanol concentrations (> 50 mM) potentiate release. In vivo, ethanol, at a behaviorally relevant blood ethanol concentration (126 mg%), does not produce a significant difference in AVP content in brain although there is a consistent trend towards an increase in the hypothalamus and neurohypophysis. The results are considered in relation to the effects of ethanol on biogenic amine release and to memory impairments induced by low doses of acute ethanol exposure.

Original language	English (US)
Pages (from-to)	213-217
Number of pages	5
Journal	Neuroscience Letters
Volume	67
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(86)90400-3
State	Published - Jun 18 1986

Keywords

alcohol
brain
ethanol
vasopressin
vasopressin content
vasopressin release

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(86)90400-3

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title = "In vitro inhibition of vasopressin release in brain by behaviorally relevant ethanol concentrations",

abstract = "We have investigated the effect of ethanol upon vasopressin (AVP) content in brain and upon in-vitro release of AVP from the rat median eminence. In-vitro ethanol concentrations (5-25 mM), comparable to behaviorally relevant blood ethanol levels, induce a substantial inhibition of AVP release from the median eminence, whereas higher ethanol concentrations (> 50 mM) potentiate release. In vivo, ethanol, at a behaviorally relevant blood ethanol concentration (126 mg%), does not produce a significant difference in AVP content in brain although there is a consistent trend towards an increase in the hypothalamus and neurohypophysis. The results are considered in relation to the effects of ethanol on biogenic amine release and to memory impairments induced by low doses of acute ethanol exposure.",

keywords = "alcohol, brain, ethanol, vasopressin, vasopressin content, vasopressin release",

author = "Brinton, {Roberta E.} and Raphael Gruener and Pushpa Deshmukh and Yamamura, {Henry I.}",

note = "Funding Information: The authors wish to express their gratitude to Drs. Blake Gosnell and Robert Spencer for their assistance during different phases of this study. Dr. Bruce S. McEwen provided invaluable evaluation of the data and critical reading of the manuscript for which we extend our appreciation. This research was supported by",

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AU - Brinton, Roberta E.

AU - Gruener, Raphael

AU - Deshmukh, Pushpa

AU - Yamamura, Henry I.

N1 - Funding Information: The authors wish to express their gratitude to Drs. Blake Gosnell and Robert Spencer for their assistance during different phases of this study. Dr. Bruce S. McEwen provided invaluable evaluation of the data and critical reading of the manuscript for which we extend our appreciation. This research was supported by

PY - 1986/6/18

Y1 - 1986/6/18

N2 - We have investigated the effect of ethanol upon vasopressin (AVP) content in brain and upon in-vitro release of AVP from the rat median eminence. In-vitro ethanol concentrations (5-25 mM), comparable to behaviorally relevant blood ethanol levels, induce a substantial inhibition of AVP release from the median eminence, whereas higher ethanol concentrations (> 50 mM) potentiate release. In vivo, ethanol, at a behaviorally relevant blood ethanol concentration (126 mg%), does not produce a significant difference in AVP content in brain although there is a consistent trend towards an increase in the hypothalamus and neurohypophysis. The results are considered in relation to the effects of ethanol on biogenic amine release and to memory impairments induced by low doses of acute ethanol exposure.

AB - We have investigated the effect of ethanol upon vasopressin (AVP) content in brain and upon in-vitro release of AVP from the rat median eminence. In-vitro ethanol concentrations (5-25 mM), comparable to behaviorally relevant blood ethanol levels, induce a substantial inhibition of AVP release from the median eminence, whereas higher ethanol concentrations (> 50 mM) potentiate release. In vivo, ethanol, at a behaviorally relevant blood ethanol concentration (126 mg%), does not produce a significant difference in AVP content in brain although there is a consistent trend towards an increase in the hypothalamus and neurohypophysis. The results are considered in relation to the effects of ethanol on biogenic amine release and to memory impairments induced by low doses of acute ethanol exposure.

KW - alcohol

KW - brain

KW - ethanol

KW - vasopressin

KW - vasopressin content

KW - vasopressin release

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ER -

In vitro inhibition of vasopressin release in brain by behaviorally relevant ethanol concentrations

Abstract

Keywords

ASJC Scopus subject areas

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