TY - JOUR
T1 - In vitro antiviral effect of Mexican and Brazilian propolis and phenolic compounds against human coronavirus 229E
AU - Silva-Beltrán, Norma Patricia
AU - Galvéz-Ruíz, Juan Carlos
AU - Ikner, Luisa A.
AU - Umsza-Guez, Marcelo Andrés
AU - de Paula Castro, Thiago Luiz
AU - Gerba, Charles P.
N1 - Publisher Copyright:
© 2022 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2022
Y1 - 2022
N2 - Propolis is a resinous substance collected by bees (Apis mellifera). It is used for its biological properties. This natural product is available as a safe therapeutic option. Herein, we report the antiviral effects of brown propolis extract from Mexico and green and red propolis extracts from Brazil, as well as their phenolic compounds (quercetin, caffeic acid, and rutin) in preventing infection of MRC-5 cells by HCoV-229E. Normal human fibroblast lung cells (MRC-5) were used to determine the cytotoxicity of the compounds. All samples studied showed antiviral activity. Green and brown propolis extracts, and quercetin exhibited the best EC50 values with values of 19.080, 11.240, and 77.208 µg/mL against HCoV-229E, respectively, and with TC50 of 62.19, 29.192, and 298 µg/mL on MRC-5 cells, respectively. These results are the first in vitro study of the effects of propolis on HCoV-229E and provide the basis for the development of natural formulations against other coronavirus strains.
AB - Propolis is a resinous substance collected by bees (Apis mellifera). It is used for its biological properties. This natural product is available as a safe therapeutic option. Herein, we report the antiviral effects of brown propolis extract from Mexico and green and red propolis extracts from Brazil, as well as their phenolic compounds (quercetin, caffeic acid, and rutin) in preventing infection of MRC-5 cells by HCoV-229E. Normal human fibroblast lung cells (MRC-5) were used to determine the cytotoxicity of the compounds. All samples studied showed antiviral activity. Green and brown propolis extracts, and quercetin exhibited the best EC50 values with values of 19.080, 11.240, and 77.208 µg/mL against HCoV-229E, respectively, and with TC50 of 62.19, 29.192, and 298 µg/mL on MRC-5 cells, respectively. These results are the first in vitro study of the effects of propolis on HCoV-229E and provide the basis for the development of natural formulations against other coronavirus strains.
KW - caffeic acid
KW - coronavirus
KW - propolis
KW - quercetin
KW - rutin
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U2 - 10.1080/09603123.2022.2110576
DO - 10.1080/09603123.2022.2110576
M3 - Article
C2 - 35951754
AN - SCOPUS:85136965953
SN - 0960-3123
VL - 33
SP - 1591
EP - 1603
JO - International Journal of Environmental Health Research
JF - International Journal of Environmental Health Research
IS - 12
ER -