TY - JOUR
T1 - In utero Epstein-Barr virus (infectious mononucleosis) infection
AU - Goldberg, G. N.
AU - Fulginiti, V. A.
AU - Ray, C. G.
AU - Ferry, P.
AU - Jones, J. F.
AU - Cross, Harold E
AU - Minnich, L.
PY - 1981/11/13
Y1 - 1981/11/13
N2 - A male infant infected in utero with Epstein-Barr virus (EBV) demonstrated a syndrome of multiple congenital anomalies (micrognathia, cryptorchidism, central cataracts), hypotonia, thrombocytopenia, persistent monocytosis, proteinuria, and multiple areas of metaphysitis at birth. Lymphocytes were Epstein-Barr nuclear antigen (EBNA) positive (18%) and persisted in culture for three months. He had antibody to early antigen (anti-EA), IgM-viral capsid (anti VCA), and EBNA (anti-EBNA) detectable at 22 days of age. All attempts to isolate infectious agents or to serologically identify other infectious causes for this syndrome were negative.
AB - A male infant infected in utero with Epstein-Barr virus (EBV) demonstrated a syndrome of multiple congenital anomalies (micrognathia, cryptorchidism, central cataracts), hypotonia, thrombocytopenia, persistent monocytosis, proteinuria, and multiple areas of metaphysitis at birth. Lymphocytes were Epstein-Barr nuclear antigen (EBNA) positive (18%) and persisted in culture for three months. He had antibody to early antigen (anti-EA), IgM-viral capsid (anti VCA), and EBNA (anti-EBNA) detectable at 22 days of age. All attempts to isolate infectious agents or to serologically identify other infectious causes for this syndrome were negative.
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U2 - 10.1001/jama.246.14.1579
DO - 10.1001/jama.246.14.1579
M3 - Article
C2 - 6268854
SN - 0098-7484
VL - 246
SP - 1579
EP - 1581
JO - Journal of the American Medical Association
JF - Journal of the American Medical Association
IS - 14
ER -