In utero Epstein-Barr virus (infectious mononucleosis) infection

G. N. Goldberg, V. A. Fulginiti, C. G. Ray, P. Ferry, J. F. Jones, Harold E Cross, L. Minnich

Research output: Contribution to journalArticlepeer-review


A male infant infected in utero with Epstein-Barr virus (EBV) demonstrated a syndrome of multiple congenital anomalies (micrognathia, cryptorchidism, central cataracts), hypotonia, thrombocytopenia, persistent monocytosis, proteinuria, and multiple areas of metaphysitis at birth. Lymphocytes were Epstein-Barr nuclear antigen (EBNA) positive (18%) and persisted in culture for three months. He had antibody to early antigen (anti-EA), IgM-viral capsid (anti VCA), and EBNA (anti-EBNA) detectable at 22 days of age. All attempts to isolate infectious agents or to serologically identify other infectious causes for this syndrome were negative.

Original languageEnglish (US)
Pages (from-to)1579-1581
Number of pages3
JournalJournal of the American Medical Association
Issue number14
StatePublished - Nov 13 1981

ASJC Scopus subject areas

  • Medicine(all)


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