In Utero Epstein-Barr Virus (Infectious Mononucleosis) Infection

Gerald N. Goldberg; Vincent A. Fulginiti; C. George Ray; Peggy Ferry; James F. Jones; Linda Minnich; Harold Cross

doi:10.1001/jama.1981.03320140067034

In Utero Epstein-Barr Virus (Infectious Mononucleosis) Infection

Gerald N. Goldberg
, Vincent A. Fulginiti
, C. George Ray
, Peggy Ferry
, James F. Jones
, Linda Minnich
, Harold Cross

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

A male infant infected in utero with Epstein-Barr virus (EBV) demonstrated a syndrome of multiple congenital anomalies (micrognathia, cryptorchidism, central cataracts), hypotonia, thrombocytopenia, persistent monocytosis, proteinuria, and multiple areas of metaphysitis at birth. Lymphocytes were Epstein-Barr nuclear antigen (EBNA) positive (18%) and persisted in culture for three months. He had antibody to early antigen (anti-EA), IgM-viral capsid (anti-VCA), and EBNA (anti-EBNA) detectable at 22 days of age. All attempts to isolate infectious agents or to serologically identify other infectious causes for his syndrome were negative.

Original language	English (US)
Pages (from-to)	1579-1581
Number of pages	3
Journal	JAMA: The Journal of the American Medical Association
Volume	246
Issue number	14
DOIs	https://doi.org/10.1001/jama.1981.03320140067034
State	Published - Oct 2 1981
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1001/jama.1981.03320140067034

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title = "In Utero Epstein-Barr Virus (Infectious Mononucleosis) Infection",

abstract = "A male infant infected in utero with Epstein-Barr virus (EBV) demonstrated a syndrome of multiple congenital anomalies (micrognathia, cryptorchidism, central cataracts), hypotonia, thrombocytopenia, persistent monocytosis, proteinuria, and multiple areas of metaphysitis at birth. Lymphocytes were Epstein-Barr nuclear antigen (EBNA) positive (18\%) and persisted in culture for three months. He had antibody to early antigen (anti-EA), IgM-viral capsid (anti-VCA), and EBNA (anti-EBNA) detectable at 22 days of age. All attempts to isolate infectious agents or to serologically identify other infectious causes for his syndrome were negative.",

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AU - Goldberg, Gerald N.

AU - Fulginiti, Vincent A.

AU - Ray, C. George

AU - Ferry, Peggy

AU - Jones, James F.

AU - Minnich, Linda

AU - Cross, Harold

PY - 1981/10/2

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AB - A male infant infected in utero with Epstein-Barr virus (EBV) demonstrated a syndrome of multiple congenital anomalies (micrognathia, cryptorchidism, central cataracts), hypotonia, thrombocytopenia, persistent monocytosis, proteinuria, and multiple areas of metaphysitis at birth. Lymphocytes were Epstein-Barr nuclear antigen (EBNA) positive (18%) and persisted in culture for three months. He had antibody to early antigen (anti-EA), IgM-viral capsid (anti-VCA), and EBNA (anti-EBNA) detectable at 22 days of age. All attempts to isolate infectious agents or to serologically identify other infectious causes for his syndrome were negative.

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In Utero Epstein-Barr Virus (Infectious Mononucleosis) Infection

Abstract

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