TY - JOUR
T1 - In Utero Epstein-Barr Virus (Infectious Mononucleosis) Infection
AU - Goldberg, Gerald N.
AU - Fulginiti, Vincent A.
AU - Ray, C. George
AU - Ferry, Peggy
AU - Jones, James F.
AU - Minnich, Linda
AU - Cross, Harold
PY - 1981/10/2
Y1 - 1981/10/2
N2 - A male infant infected in utero with Epstein-Barr virus (EBV) demonstrated a syndrome of multiple congenital anomalies (micrognathia, cryptorchidism, central cataracts), hypotonia, thrombocytopenia, persistent monocytosis, proteinuria, and multiple areas of metaphysitis at birth. Lymphocytes were Epstein-Barr nuclear antigen (EBNA) positive (18%) and persisted in culture for three months. He had antibody to early antigen (anti-EA), IgM-viral capsid (anti-VCA), and EBNA (anti-EBNA) detectable at 22 days of age. All attempts to isolate infectious agents or to serologically identify other infectious causes for his syndrome were negative.
AB - A male infant infected in utero with Epstein-Barr virus (EBV) demonstrated a syndrome of multiple congenital anomalies (micrognathia, cryptorchidism, central cataracts), hypotonia, thrombocytopenia, persistent monocytosis, proteinuria, and multiple areas of metaphysitis at birth. Lymphocytes were Epstein-Barr nuclear antigen (EBNA) positive (18%) and persisted in culture for three months. He had antibody to early antigen (anti-EA), IgM-viral capsid (anti-VCA), and EBNA (anti-EBNA) detectable at 22 days of age. All attempts to isolate infectious agents or to serologically identify other infectious causes for his syndrome were negative.
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U2 - 10.1001/jama.1981.03320140067034
DO - 10.1001/jama.1981.03320140067034
M3 - Article
C2 - 6268854
AN - SCOPUS:84943672631
SN - 0098-7484
VL - 246
SP - 1579
EP - 1581
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
IS - 14
ER -