In situ electrostimulation drives a regenerative shift in the zone of infarcted myocardium

Cristiano Spadaccio; Alberto Rainer; Federico De Marco; Mario Lusini; Paolo Gallo; Pietro Sedati; Andrea Onetti Muda; Stefano de Porcellinis; Chiara Gregorj; Giuseppe Avvisati; Marcella Trombetta; Massimo Chello; Elvio Covino; David A. Bull; Amit N. Patel; Jorge A. Genovese

doi:10.3727/096368912X652977

In situ electrostimulation drives a regenerative shift in the zone of infarcted myocardium

Cristiano Spadaccio, Alberto Rainer, Federico De Marco, Mario Lusini, Paolo Gallo, Pietro Sedati, Andrea Onetti Muda, Stefano de Porcellinis, Chiara Gregorj, Giuseppe Avvisati, Marcella Trombetta, Massimo Chello, Elvio Covino, David A. Bull, Amit N. Patel, Jorge A. Genovese

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Electrostimulation represents a well-known trophic factor for different tissues. In vitro electrostimulation of non-stem and stem cells induces myogenic predifferentiation and may be a powerful tool to generate cells with the capacity to respond to local areas of injury. We evaluated the effects of in vivo electrostimulation on infarcted myocardium using a miniaturized multiparameter implantable stimulator in rats. Parameters of electrostimulation were organized to avoid a direct driving or pacing of native heart rhythm. Electrical stimuli were delivered for 14 days across the scar site. In situ electrostimulation used as a cell-free, cytokine-free stimulation system, improved myocardial function, and increased angiogenesis through endothelial progenitor cell migration and production of vascular endothelial growth factor (VEGF). In situ electrostimulation represents a novel means to stimulate repair of the heart and other organs, as well as to precondition tissues for treatment with cell-based therapies.

Original language	English (US)
Pages (from-to)	493-503
Number of pages	11
Journal	Cell transplantation
Volume	22
Issue number	3
DOIs	https://doi.org/10.3727/096368912X652977
State	Published - 2013
Externally published	Yes

Keywords

Electrostimulation (ES)
Infarct
Myocardium
Stem cells

ASJC Scopus subject areas

Biomedical Engineering
Cell Biology
Transplantation

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10.3727/096368912X652977

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Spadaccio, C., Rainer, A., De Marco, F., Lusini, M., Gallo, P., Sedati, P., Muda, A. O., de Porcellinis, S., Gregorj, C., Avvisati, G., Trombetta, M., Chello, M., Covino, E., Bull, D. A., Patel, A. N., & Genovese, J. A. (2013). In situ electrostimulation drives a regenerative shift in the zone of infarcted myocardium. Cell transplantation, 22(3), 493-503. https://doi.org/10.3727/096368912X652977

Spadaccio, C, Rainer, A, De Marco, F, Lusini, M, Gallo, P, Sedati, P, Muda, AO, de Porcellinis, S, Gregorj, C, Avvisati, G, Trombetta, M, Chello, M, Covino, E, Bull, DA, Patel, AN & Genovese, JA 2013, 'In situ electrostimulation drives a regenerative shift in the zone of infarcted myocardium', Cell transplantation, vol. 22, no. 3, pp. 493-503. https://doi.org/10.3727/096368912X652977

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abstract = "Electrostimulation represents a well-known trophic factor for different tissues. In vitro electrostimulation of non-stem and stem cells induces myogenic predifferentiation and may be a powerful tool to generate cells with the capacity to respond to local areas of injury. We evaluated the effects of in vivo electrostimulation on infarcted myocardium using a miniaturized multiparameter implantable stimulator in rats. Parameters of electrostimulation were organized to avoid a direct driving or pacing of native heart rhythm. Electrical stimuli were delivered for 14 days across the scar site. In situ electrostimulation used as a cell-free, cytokine-free stimulation system, improved myocardial function, and increased angiogenesis through endothelial progenitor cell migration and production of vascular endothelial growth factor (VEGF). In situ electrostimulation represents a novel means to stimulate repair of the heart and other organs, as well as to precondition tissues for treatment with cell-based therapies.",

keywords = "Electrostimulation (ES), Infarct, Myocardium, Stem cells",

author = "Cristiano Spadaccio and Alberto Rainer and {De Marco}, Federico and Mario Lusini and Paolo Gallo and Pietro Sedati and Muda, {Andrea Onetti} and {de Porcellinis}, Stefano and Chiara Gregorj and Giuseppe Avvisati and Marcella Trombetta and Massimo Chello and Elvio Covino and Bull, {David A.} and Patel, {Amit N.} and Genovese, {Jorge A.}",

year = "2013",

doi = "10.3727/096368912X652977",

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AU - Spadaccio, Cristiano

AU - Rainer, Alberto

AU - De Marco, Federico

AU - Lusini, Mario

AU - Gallo, Paolo

AU - Sedati, Pietro

AU - Muda, Andrea Onetti

AU - de Porcellinis, Stefano

AU - Gregorj, Chiara

AU - Avvisati, Giuseppe

AU - Trombetta, Marcella

AU - Chello, Massimo

AU - Covino, Elvio

AU - Bull, David A.

AU - Patel, Amit N.

AU - Genovese, Jorge A.

PY - 2013

Y1 - 2013

N2 - Electrostimulation represents a well-known trophic factor for different tissues. In vitro electrostimulation of non-stem and stem cells induces myogenic predifferentiation and may be a powerful tool to generate cells with the capacity to respond to local areas of injury. We evaluated the effects of in vivo electrostimulation on infarcted myocardium using a miniaturized multiparameter implantable stimulator in rats. Parameters of electrostimulation were organized to avoid a direct driving or pacing of native heart rhythm. Electrical stimuli were delivered for 14 days across the scar site. In situ electrostimulation used as a cell-free, cytokine-free stimulation system, improved myocardial function, and increased angiogenesis through endothelial progenitor cell migration and production of vascular endothelial growth factor (VEGF). In situ electrostimulation represents a novel means to stimulate repair of the heart and other organs, as well as to precondition tissues for treatment with cell-based therapies.

AB - Electrostimulation represents a well-known trophic factor for different tissues. In vitro electrostimulation of non-stem and stem cells induces myogenic predifferentiation and may be a powerful tool to generate cells with the capacity to respond to local areas of injury. We evaluated the effects of in vivo electrostimulation on infarcted myocardium using a miniaturized multiparameter implantable stimulator in rats. Parameters of electrostimulation were organized to avoid a direct driving or pacing of native heart rhythm. Electrical stimuli were delivered for 14 days across the scar site. In situ electrostimulation used as a cell-free, cytokine-free stimulation system, improved myocardial function, and increased angiogenesis through endothelial progenitor cell migration and production of vascular endothelial growth factor (VEGF). In situ electrostimulation represents a novel means to stimulate repair of the heart and other organs, as well as to precondition tissues for treatment with cell-based therapies.

KW - Electrostimulation (ES)

KW - Infarct

KW - Myocardium

KW - Stem cells

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In situ electrostimulation drives a regenerative shift in the zone of infarcted myocardium

Abstract

Keywords

ASJC Scopus subject areas

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