In situ electrostimulation drives a regenerative shift in the zone of infarcted myocardium

Cristiano Spadaccio, Alberto Rainer, Federico De Marco, Mario Lusini, Paolo Gallo, Pietro Sedati, Andrea Onetti Muda, Stefano de Porcellinis, Chiara Gregorj, Giuseppe Avvisati, Marcella Trombetta, Massimo Chello, Elvio Covino, David A. Bull, Amit N. Patel, Jorge A. Genovese

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Electrostimulation represents a well-known trophic factor for different tissues. In vitro electrostimulation of non-stem and stem cells induces myogenic predifferentiation and may be a powerful tool to generate cells with the capacity to respond to local areas of injury. We evaluated the effects of in vivo electrostimulation on infarcted myocardium using a miniaturized multiparameter implantable stimulator in rats. Parameters of electrostimulation were organized to avoid a direct driving or pacing of native heart rhythm. Electrical stimuli were delivered for 14 days across the scar site. In situ electrostimulation used as a cell-free, cytokine-free stimulation system, improved myocardial function, and increased angiogenesis through endothelial progenitor cell migration and production of vascular endothelial growth factor (VEGF). In situ electrostimulation represents a novel means to stimulate repair of the heart and other organs, as well as to precondition tissues for treatment with cell-based therapies.

Original languageEnglish (US)
Pages (from-to)493-503
Number of pages11
JournalCell transplantation
Volume22
Issue number3
DOIs
StatePublished - 2013
Externally publishedYes

Keywords

  • Electrostimulation (ES)
  • Infarct
  • Myocardium
  • Stem cells

ASJC Scopus subject areas

  • Biomedical Engineering
  • Cell Biology
  • Transplantation

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