Improved uniformity of aortic enhancement with customized contrast medium injection protocols at CT angiography

Dominik Fleischmann, Geoffrey D. Rubin, A. Alexander Bankier, Karl Hittmair

Research output: Contribution to journalArticlepeer-review

233 Scopus citations


PURPOSE: To compare the uniformity of aortoiliac opacification obtained from uniphasic contrast medium injections versus individualized biphasic injections at computed tomographic (CT) angiography. MATERIALS AND METHODS: Thirty-two patients with an abdominal aortic aneurysm underwent CT angiography. In 16 patients (group 1), 120 mL of contrast material was administered at a flow rate of 4 mL/sec. In the other 16 patients (group 2), biphasic injection protocols were computed by using mathematic deconvolution of each patient's time-attenuation response to a standardized test injection. Attenuation uniformity was quantified as the 'plateau deviation' of enhancement values, which were calculated as the SD of the time-contiguous attenuation values observed during the 30-second scanning period. RESULTS: Group 2 patients received between 77 and 165 mL (mean, 115 mL) of contrast medium. Initial flow rates ranged from 4.1 to 10.0 mL/sec (mean, 6.8 mL/sec) for the first 4-6 seconds; continuing flow rates ranged from 2.0 to 4.8 mL/sec (mean, 3.1 mL/sec) for the remaining 24-26 seconds. The plateau deviation was significantly smaller in group 2 patients (19 HU) versus group 1 patients (38 HU, P < .001). CONCLUSION: At CT angiography, tailored biphasic injections led to more uniform aortoiliac enhancement, compared with standard uniphasic injections of contrast medium.

Original languageEnglish (US)
Pages (from-to)363-371
Number of pages9
Issue number2
StatePublished - Feb 2000
Externally publishedYes


  • Aneurysm, aortic
  • Aorta, CT
  • Arteries, CT
  • Arteries, iliac
  • Computed tomography (CT), angiography
  • Computed tomography (CT), contrast enhancement

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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