Abstract
Study Objectives The aim of this study was to determine the effects of an antibiotic strategy with intravenous (IV) continuous infusion of a β-lactam (CIBL) antibiotic and high-dose extended-interval (HDEI) tobramycin upon outcomes in patients with cystic fibrosis (CF) requiring invasive mechanical ventilation (IMV) for acute respiratory failure. Design The study was a retrospective review from June 1, 2006, to December 1, 2010, of patients at a university hospital with an adult CF center. Results The study population included adult CF patients requiring IMV. A total of 15 hospitalizations with IMV episodes were reviewed, involving 10 adult (31.4±11.1 years) CF patients with end-stage lung disease (FEV 1 = 23.6±7.8% predicted) and malnutrition (body mass index = 20.5±3.1). Each patient survived to discharge and to follow-up 6 months later without the need for lung transplantation during the study period. Conclusions A novel antibiotic strategy with a CIBL antibiotic and HDEI tobramycin improved survival in a small cohort of critically ill CF patients with end-stage lung disease and malnutrition requiring IMV.
Original language | English (US) |
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Pages (from-to) | 409-415 |
Number of pages | 7 |
Journal | Lung |
Volume | 189 |
Issue number | 5 |
DOIs | |
State | Published - Oct 2011 |
Externally published | Yes |
Keywords
- Continuous infusion
- Cystic fibrosis
- Invasive mechanical ventilation
- Pseudomonas aeruginosa
- Respiratory failure
- Tobramycin
- β-Lactam antibiotic
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine