Improved delineation of short cortical association fibers and gray/white matter boundary using whole-brain three-dimensional diffusion tensor imaging at submillimeter spatial resolution

Allen W. Song, Hing Chiu Chang, Christopher Petty, Arnaud Guidon, Nan Kuei Chen

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Recent emergence of human connectome imaging has led to a high demand on angular and spatial resolutions for diffusion magnetic resonance imaging (MRI). While there have been significant growths in high angular resolution diffusion imaging, the improvement in spatial resolution is still limited due to a number of technical challenges, such as the low signal-to-noise ratio and high motion artifacts. As a result, the benefit of a high spatial resolution in the whole-brain connectome imaging has not been fully evaluated in vivo. In this brief report, the impact of spatial resolution was assessed in a newly acquired whole-brain three-dimensional diffusion tensor imaging data set with an isotropic spatial resolution of 0.85 mm. It was found that the delineation of short cortical association fibers is drastically improved as well as the definition of fiber pathway endings into the gray/white matter boundary-both of which will help construct a more accurate structural map of the human brain connectome.

Original languageEnglish (US)
Pages (from-to)636-640
Number of pages5
JournalBrain Connectivity
Volume4
Issue number9
DOIs
StatePublished - Nov 1 2014
Externally publishedYes

Keywords

  • DTI
  • brain
  • connectome
  • high resolution
  • short cortical association fibers

ASJC Scopus subject areas

  • Neuroscience(all)

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