Improved analogs and novel delivery systems for somatostatin octapeptides

J. P. Moreau; S. Kim; J. Z. Dong; F. Ignatious; S. Jackson; S. C. Moreau; B. A. Morgan; F. Touraud; J. E. Taylor; B. Tissier; M. Pellet; W. Murphy; T. Davis

doi:10.1016/S0026-0495(96)90074-8

Improved analogs and novel delivery systems for somatostatin octapeptides

J. P. Moreau
, S. Kim
, J. Z. Dong
, F. Ignatious
, S. Jackson
, S. C. Moreau
, B. A. Morgan
, F. Touraud
, J. E. Taylor
, B. Tissier
, M. Pellet
, W. Murphy
, T. Davis

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Appropriate N-terminus modification can result in somatostatin (SRIF) octapeptide analogs that are both more potent and more selective in vitro for the human SRIF receptor type 2 (hsst₂). In addition, these modifications can improve the duration of action and bioavailability of SRIF analogs following parenteral administration, as shown by both pharmacological and distribution studies in vivo with BIM-23190 and BIM-23197 in the rat.

Original language	English (US)
Pages (from-to)	24-26
Number of pages	3
Journal	Metabolism: Clinical and Experimental
Volume	45
Issue number	SUPPL.1
DOIs	https://doi.org/10.1016/S0026-0495(96)90074-8
State	Published - 1996

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

Access to Document

10.1016/S0026-0495(96)90074-8

Cite this

@article{b2e837beb5704b189b2a3e250936c00e,

title = "Improved analogs and novel delivery systems for somatostatin octapeptides",

abstract = "Appropriate N-terminus modification can result in somatostatin (SRIF) octapeptide analogs that are both more potent and more selective in vitro for the human SRIF receptor type 2 (hsst2). In addition, these modifications can improve the duration of action and bioavailability of SRIF analogs following parenteral administration, as shown by both pharmacological and distribution studies in vivo with BIM-23190 and BIM-23197 in the rat.",

author = "Moreau, \{J. P.\} and S. Kim and Dong, \{J. Z.\} and F. Ignatious and S. Jackson and Moreau, \{S. C.\} and Morgan, \{B. A.\} and F. Touraud and Taylor, \{J. E.\} and B. Tissier and M. Pellet and W. Murphy and T. Davis",

year = "1996",

doi = "10.1016/S0026-0495(96)90074-8",

language = "English (US)",

volume = "45",

pages = "24--26",

journal = "Metabolism: Clinical and Experimental",

issn = "0026-0495",

publisher = "W.B. Saunders",

number = "SUPPL.1",

}

TY - JOUR

T1 - Improved analogs and novel delivery systems for somatostatin octapeptides

AU - Moreau, J. P.

AU - Kim, S.

AU - Dong, J. Z.

AU - Ignatious, F.

AU - Jackson, S.

AU - Moreau, S. C.

AU - Morgan, B. A.

AU - Touraud, F.

AU - Taylor, J. E.

AU - Tissier, B.

AU - Pellet, M.

AU - Murphy, W.

AU - Davis, T.

PY - 1996

Y1 - 1996

N2 - Appropriate N-terminus modification can result in somatostatin (SRIF) octapeptide analogs that are both more potent and more selective in vitro for the human SRIF receptor type 2 (hsst2). In addition, these modifications can improve the duration of action and bioavailability of SRIF analogs following parenteral administration, as shown by both pharmacological and distribution studies in vivo with BIM-23190 and BIM-23197 in the rat.

AB - Appropriate N-terminus modification can result in somatostatin (SRIF) octapeptide analogs that are both more potent and more selective in vitro for the human SRIF receptor type 2 (hsst2). In addition, these modifications can improve the duration of action and bioavailability of SRIF analogs following parenteral administration, as shown by both pharmacological and distribution studies in vivo with BIM-23190 and BIM-23197 in the rat.

UR - https://www.scopus.com/pages/publications/0038573796

UR - https://www.scopus.com/pages/publications/0038573796#tab=citedBy

U2 - 10.1016/S0026-0495(96)90074-8

DO - 10.1016/S0026-0495(96)90074-8

M3 - Article

C2 - 8769374

AN - SCOPUS:0038573796

SN - 0026-0495

VL - 45

SP - 24

EP - 26

JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

IS - SUPPL.1

ER -

Improved analogs and novel delivery systems for somatostatin octapeptides

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this