Improved analogs and novel delivery systems for somatostatin octapeptides

J. P. Moreau; S. Kim; J. Z. Dong; F. Ignatious; S. Jackson; S. C. Moreau; B. A. Morgan; F. Touraud; J. E. Taylor; B. Tissier; M. Pellet; W. Murphy; T. Davis

doi:10.1016/S0026-0495(96)90074-8

Improved analogs and novel delivery systems for somatostatin octapeptides

J. P. Moreau, S. Kim, J. Z. Dong, F. Ignatious, S. Jackson, S. C. Moreau, B. A. Morgan, F. Touraud, J. E. Taylor, B. Tissier, M. Pellet, W. Murphy, T. Davis

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Appropriate N-terminus modification can result in somatostatin (SRIF) octapeptide analogs that are both more potent and more selective in vitro for the human SRIF receptor type 2 (hsst₂). In addition, these modifications can improve the duration of action and bioavailability of SRIF analogs following parenteral administration, as shown by both pharmacological and distribution studies in vivo with BIM-23190 and BIM-23197 in the rat.

Original language	English (US)
Pages (from-to)	24-26
Number of pages	3
Journal	Metabolism: Clinical and Experimental
Volume	45
Issue number	SUPPL.1
DOIs	https://doi.org/10.1016/S0026-0495(96)90074-8
State	Published - 1996

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/S0026-0495(96)90074-8

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title = "Improved analogs and novel delivery systems for somatostatin octapeptides",

abstract = "Appropriate N-terminus modification can result in somatostatin (SRIF) octapeptide analogs that are both more potent and more selective in vitro for the human SRIF receptor type 2 (hsst2). In addition, these modifications can improve the duration of action and bioavailability of SRIF analogs following parenteral administration, as shown by both pharmacological and distribution studies in vivo with BIM-23190 and BIM-23197 in the rat.",

author = "Moreau, {J. P.} and S. Kim and Dong, {J. Z.} and F. Ignatious and S. Jackson and Moreau, {S. C.} and Morgan, {B. A.} and F. Touraud and Taylor, {J. E.} and B. Tissier and M. Pellet and W. Murphy and T. Davis",

year = "1996",

doi = "10.1016/S0026-0495(96)90074-8",

language = "English (US)",

volume = "45",

pages = "24--26",

journal = "Metabolism: Clinical and Experimental",

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TY - JOUR

T1 - Improved analogs and novel delivery systems for somatostatin octapeptides

AU - Moreau, J. P.

AU - Kim, S.

AU - Dong, J. Z.

AU - Ignatious, F.

AU - Jackson, S.

AU - Moreau, S. C.

AU - Morgan, B. A.

AU - Touraud, F.

AU - Taylor, J. E.

AU - Tissier, B.

AU - Pellet, M.

AU - Murphy, W.

AU - Davis, T.

PY - 1996

Y1 - 1996

N2 - Appropriate N-terminus modification can result in somatostatin (SRIF) octapeptide analogs that are both more potent and more selective in vitro for the human SRIF receptor type 2 (hsst2). In addition, these modifications can improve the duration of action and bioavailability of SRIF analogs following parenteral administration, as shown by both pharmacological and distribution studies in vivo with BIM-23190 and BIM-23197 in the rat.

AB - Appropriate N-terminus modification can result in somatostatin (SRIF) octapeptide analogs that are both more potent and more selective in vitro for the human SRIF receptor type 2 (hsst2). In addition, these modifications can improve the duration of action and bioavailability of SRIF analogs following parenteral administration, as shown by both pharmacological and distribution studies in vivo with BIM-23190 and BIM-23197 in the rat.

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UR - http://www.scopus.com/inward/citedby.url?scp=0038573796&partnerID=8YFLogxK

U2 - 10.1016/S0026-0495(96)90074-8

DO - 10.1016/S0026-0495(96)90074-8

M3 - Article

C2 - 8769374

AN - SCOPUS:0038573796

SN - 0026-0495

VL - 45

SP - 24

EP - 26

JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

IS - SUPPL.1

ER -

Improved analogs and novel delivery systems for somatostatin octapeptides

Abstract

ASJC Scopus subject areas

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