Implications of Look AHEAD for clinical trials and clinical practice

for The Look AHEAD Research Group

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Look AHEAD (Action for Health in Diabetes) was a randomized clinical trial designed to examine the long-term health effects of weight loss in overweight and obese individuals with type 2 diabetes. The primary result was that the incidence of cardiovascular events over a median follow-up of 9.6 years was not reduced in the Intensive Lifestyle Group relative to the control group. This finding is discussed, with emphasis on its implications for design of trials and clinical treatment of obese persons with type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)1183-1191
Number of pages9
JournalDiabetes, Obesity and Metabolism
Issue number12
StatePublished - Dec 1 2014
Externally publishedYes


  • Cardiovascular disease
  • Dietary intervention
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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