Imperfect interfaces

Xavier Ysern, Hongmin Li, Roy A. Mariuzza

Research output: Contribution to journalShort surveypeer-review

33 Scopus citations


The crystal structure of a T cell receptor bound to a self peptide- major histocompatibility complex antigen reveals poor shape complementarity in the interface between the two proteins, as well as large conformational changes in the T cell receptor combining site upon ligand binding.

Original languageEnglish (US)
Pages (from-to)412-414
Number of pages3
JournalNature Structural Biology
Issue number6
StatePublished - Jun 1998
Externally publishedYes

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Genetics


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