Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment

Jon Valla; Lonnie Schneider; Tracy Niedzielko; Keith D. Coon; Richard Caselli; Marwan N. Sabbagh; Geoffrey L. Ahern; Leslie Baxter; Gene Alexander; Douglas G. Walker; Eric M. Reiman

doi:10.1016/j.mito.2006.10.004

Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment

Jon Valla, Lonnie Schneider, Tracy Niedzielko, Keith D. Coon, Richard Caselli, Marwan N. Sabbagh, Geoffrey L. Ahern, Leslie Baxter, Gene Alexander, Douglas G. Walker, Eric M. Reiman

Research output: Contribution to journal › Article › peer-review

147 Scopus citations

Abstract

Mitochondrial abnormalities are found in Alzheimer's disease (AD), but previous reports have not examined at-risk groups. In subjects with AD, mild cognitive impairment (MCI), and non-demented aged controls, platelet and lymphocyte mitochondria were isolated and analyzed for Complexes I, III, and IV of the electron transport chain. Western blots were used to control for differential enrichment of samples. Results demonstrated significant declines in Complexes III and IV in AD, and a significant decline in Complex IV in MCI. This report confirms mitochondrial deficiencies in AD, extends them to MCI, and suggests they are present at the earliest symptomatic stages of disease.

Original language	English (US)
Pages (from-to)	323-330
Number of pages	8
Journal	Mitochondrion
Volume	6
Issue number	6
DOIs	https://doi.org/10.1016/j.mito.2006.10.004
State	Published - Dec 2006

Keywords

Alzheimer's disease
At-risk population
Cytochrome oxidase
Cytochrome reductase
Electron transport chain
Mild cognitive impairment

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Cell Biology

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10.1016/j.mito.2006.10.004

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@article{6ae1efa76aec43848e4c5a203f012912,

title = "Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment",

abstract = "Mitochondrial abnormalities are found in Alzheimer's disease (AD), but previous reports have not examined at-risk groups. In subjects with AD, mild cognitive impairment (MCI), and non-demented aged controls, platelet and lymphocyte mitochondria were isolated and analyzed for Complexes I, III, and IV of the electron transport chain. Western blots were used to control for differential enrichment of samples. Results demonstrated significant declines in Complexes III and IV in AD, and a significant decline in Complex IV in MCI. This report confirms mitochondrial deficiencies in AD, extends them to MCI, and suggests they are present at the earliest symptomatic stages of disease.",

keywords = "Alzheimer's disease, At-risk population, Cytochrome oxidase, Cytochrome reductase, Electron transport chain, Mild cognitive impairment",

author = "Jon Valla and Lonnie Schneider and Tracy Niedzielko and Coon, {Keith D.} and Richard Caselli and Sabbagh, {Marwan N.} and Ahern, {Geoffrey L.} and Leslie Baxter and Gene Alexander and Walker, {Douglas G.} and Reiman, {Eric M.}",

note = "Funding Information: We thank the volunteer subjects, neurologists, neuropsychologists, and clinical coordinators who participated and assisted in this study. Gale Kittle, Sandra Yee Benedetto, Linda Vetters, Marjorie Baldwin, and Michael Malek-Ahmadi provided considerable assistance. We thank our colleagues at the Mayo Clinic, Jacksonville, FL, for portions of the APOE genotyping. Support provided by the Arizona ADCC (P30 AG019610), Arizona ADCC and Alzheimer{\textquoteright}s Disease Consortium pilot grants to J.V. and K.C., the Barrow Neurological Foundation, and the Harrington Research Center.",

year = "2006",

month = dec,

doi = "10.1016/j.mito.2006.10.004",

language = "English (US)",

volume = "6",

pages = "323--330",

journal = "Mitochondrion",

issn = "1567-7249",

publisher = "Elsevier B.V.",

number = "6",

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TY - JOUR

T1 - Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment

AU - Valla, Jon

AU - Schneider, Lonnie

AU - Niedzielko, Tracy

AU - Coon, Keith D.

AU - Caselli, Richard

AU - Sabbagh, Marwan N.

AU - Ahern, Geoffrey L.

AU - Baxter, Leslie

AU - Alexander, Gene

AU - Walker, Douglas G.

AU - Reiman, Eric M.

N1 - Funding Information: We thank the volunteer subjects, neurologists, neuropsychologists, and clinical coordinators who participated and assisted in this study. Gale Kittle, Sandra Yee Benedetto, Linda Vetters, Marjorie Baldwin, and Michael Malek-Ahmadi provided considerable assistance. We thank our colleagues at the Mayo Clinic, Jacksonville, FL, for portions of the APOE genotyping. Support provided by the Arizona ADCC (P30 AG019610), Arizona ADCC and Alzheimer’s Disease Consortium pilot grants to J.V. and K.C., the Barrow Neurological Foundation, and the Harrington Research Center.

PY - 2006/12

Y1 - 2006/12

N2 - Mitochondrial abnormalities are found in Alzheimer's disease (AD), but previous reports have not examined at-risk groups. In subjects with AD, mild cognitive impairment (MCI), and non-demented aged controls, platelet and lymphocyte mitochondria were isolated and analyzed for Complexes I, III, and IV of the electron transport chain. Western blots were used to control for differential enrichment of samples. Results demonstrated significant declines in Complexes III and IV in AD, and a significant decline in Complex IV in MCI. This report confirms mitochondrial deficiencies in AD, extends them to MCI, and suggests they are present at the earliest symptomatic stages of disease.

AB - Mitochondrial abnormalities are found in Alzheimer's disease (AD), but previous reports have not examined at-risk groups. In subjects with AD, mild cognitive impairment (MCI), and non-demented aged controls, platelet and lymphocyte mitochondria were isolated and analyzed for Complexes I, III, and IV of the electron transport chain. Western blots were used to control for differential enrichment of samples. Results demonstrated significant declines in Complexes III and IV in AD, and a significant decline in Complex IV in MCI. This report confirms mitochondrial deficiencies in AD, extends them to MCI, and suggests they are present at the earliest symptomatic stages of disease.

KW - Alzheimer's disease

KW - At-risk population

KW - Cytochrome oxidase

KW - Cytochrome reductase

KW - Electron transport chain

KW - Mild cognitive impairment

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SN - 1567-7249

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EP - 330

JO - Mitochondrion

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ER -

Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment

Abstract

Keywords

ASJC Scopus subject areas

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