Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKCγ mutant mice

Chong Chen, Masanobu Kano, Asa Abeliovich, Lu Chen, Shaowen Bao, Jeansok J. Kim, Kouichi Hashimoto, Richard F. Thompson, Susumu Tonegawa

Research output: Contribution to journalArticlepeer-review

274 Scopus citations

Abstract

It is generally believed that a smooth execution of a compound movement, or motor coordination, requires learning of component movements as well as experience-based refinement of the motor program as a whole. PKCγ mutant mice display impaired motor coordination but intact eyeblink conditioning, a form of component movement learning. Cerebellar long-term depression, a putative cellular mechanism for component motor learning, is also unimpaired. Thus, PKCγ mutant mice are defective in refinement of the motor program. In the accompanying paper, we demonstrate that innervation of multiple climbing fibers onto Purkinje cells persists in adulthood in these mutant mice. We propose that this defective elimination of surplus climbing fibers underlies motor discoordination.

Original languageEnglish (US)
Pages (from-to)1233-1242
Number of pages10
JournalCell
Volume83
Issue number7
DOIs
StatePublished - Dec 29 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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