Impact of weight loss on serum leptin in obese postmenopausal women

Zaida R. Cordero-MacIntyre, Shiva Metghalchi, Jason Rosen, Warren Peters, Timothy G. Lohman, Maria Luz Fernandez

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


A 6-month weight loss program consisting of energy restriction (1,200 kcal) in combination with phentermine hydrocholoride (Fastin) treatment evaluated changes in plasma leptin, insulin, and glucose concentrations in 39 obese post-menopausal women (body mass index 30-38 kg/m2). Values for these parameters were correlated with plasma lipids concentrations and body composition measurements previously reported for this population. Over 6 months, participants had a 9% weight loss (P < 0.001) and a 9% reduction in body mass index (P < 0.001) compared to baseline with a 20% reduction in total fat mass and 25.8% in trunk fat (P < 0.001). Plasma leptin levels were reduced by 27% (P < 0.001) at 3 months and by 32% (P < 0.001) at 6 months. In contrast, plasma glucose and insulin levels did not change over time. Significant positive correlations tions were found between changes in plasma leptin and changes in LDL cholesterol (r = 0.366), weight (r = 0.570) and trunk fat (r = 0.362) over 6 months indicating that reductions in leptin are associated with improved parameters in plasma lipids and body composition.

Original languageEnglish (US)
Pages (from-to)60-67
Number of pages8
JournalJournal of Applied Research
Issue number1
StatePublished - 2004


  • Body composition
  • Insulin
  • Leptin
  • Plasma lipids
  • Post-menopausal women
  • Weight reduction

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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