Impact of treatment with continuous positive airway pressure (CPAP) on weight in obstructive sleep apnea

Stuart F. Quan, Rohit Budhiraja, Denise P. Clarke, James L. Goodwin, Daniel J. Gottlieb, Deborah A. Nichols, Richard D. Simon, Terry W. Smith, James K. Walsh, Clete A. Kushida

    Research output: Contribution to journalArticlepeer-review

    80 Scopus citations


    Study Objective: To determine the impact of continuous positive airway pressure (CPAP) on weight change in persons with obstructive sleep apnea (OSA). Design, Setting, and Participants: The Apnea Positive Pressure Long-term Efficacy Study (APPLES) was a 6-month, randomized, double-blinded sham-controlled multicenter clinical trial conducted at 5 sites in the United States. Of 1,105 participants with an apnea hypopnea index ≥ 10 events/hour initially randomized, 812 had body weight measured at baseline and after 6 months of study. Intervention: CPAP or Sham CPAP. measurements: Body weight, height, hours of CPAP or Sham CPAP use, Epworth Sleepiness Scale score. Results: Participants randomized to CPAP gained 0.35 ± 5.01 kg, whereas those on Sham CPAP lost 0.70 ± 4.03 kg (mean ± SD, p = 0.001). Amount of weight gain with CPAP was related to hours of device adherence, with each hour per night of use predicting a 0.42 kg increase in weight. This association was not noted in the Sham CPAP group. CPAP participants who used their device ≥ 4 h per night on ≥ 70% of nights gained the most weight over 6 months in comparison to non-adherent CPAP participants (1.0 ± 5.3 vs. -0.3 ± 5.0 kg, p = 0.014). Conclusions: OSA patients using CPAP may gain a modest amount of weight with the greatest weight gain found in those most compliant with CPAP.

    Original languageEnglish (US)
    Pages (from-to)989-993
    Number of pages5
    JournalJournal of Clinical Sleep Medicine
    Issue number10
    StatePublished - 2013


    • Continuous positive airway pressure
    • Obstructive sleep apnea
    • Weight

    ASJC Scopus subject areas

    • Pulmonary and Respiratory Medicine
    • Neurology
    • Clinical Neurology


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