Impact of the Cannabinoid System in Alzheimer's Disease

Shuangtao Li, Yuanbing Huang, Lijun Yu, Xiaoyu Ji, Jie Wu

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Cannabinoids are compounds isolated from cannabis and are also widely present in both nervous and immune systems of animals. In recent years, with in-depth research on cannabinoids, their clinical medicinal value has been evaluated, and many exciting achievements have been con-tinuously accumulating, especially in the field of neurodegenerative disease. Alzheimer's disease is the most common type of neurodegenerative disease that causes dementia and has become a global health problem that seriously impacts human health today. In this review, we discuss the therapeutic potential of cannabinoids for the treatment of Alzheimer’s disease. How cannabinoids act on differ-ent endocannabinoid receptor subtypes to regulate Alzheimer’s disease and the roles of the endo-cannabinoid system in Alzheimer’s disease are outlined, and the underlying mechanisms are dis-cussed. Finally, we summarize the most relevant opportunities of cannabinoid pharmacology related to Alzheimer’s disease and discuss the potential usefulness of cannabinoids in the clinical treatment of Alzheimer’s disease.

Original languageEnglish (US)
Pages (from-to)715-726
Number of pages12
JournalCurrent Neuropharmacology
Volume21
Issue number3
DOIs
StatePublished - 2023
Externally publishedYes

Keywords

  • Alzheimer's disease
  • CB1 receptor
  • CB2 receptor
  • Cannabinoids
  • endocannabinoid
  • neurodegenerative diseases

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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