Impact of cigarette smoking in type 2 diabetes development

Xi Tao Xie, Qiang Liu, Jie Wu, Makoto Wakui

Research output: Contribution to journalShort surveypeer-review

85 Scopus citations


Many patients with type 2 diabetes mellitus (DM2) are at risk for micro and macro vascular complications, which could be observed in heavy smokers. Cigarette smoking increases the risk for type 2 diabetes incidence. Nicotine, acknowledged as the major pharmacologically active chemical in tobacco, is responsible for the association between cigarette smoking and development of diabetes. This minireview summarized recent studies on nicotine effects on insulin action and insulin secretion, indicating the impact of nicotine on type 2 diabetes development.

Original languageEnglish (US)
Pages (from-to)784-787
Number of pages4
JournalActa Pharmacologica Sinica
Issue number6
StatePublished - Jun 2009
Externally publishedYes


  • Diabetes
  • Nicotinic receptor
  • Smoking

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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