TY - JOUR
T1 - Impact of atrial fibrillation on the in-hospital and long-term survival of patients with acute myocardial infarction
T2 - A community-wide perspective
AU - Goldberg, Robert J.
AU - Seeley, Dana
AU - Becker, Richard C.
AU - Brady, Priscilla
AU - Chen, Zuoyao
AU - Osganian, Voula
AU - Gore, Joel M.
AU - Alpert, Joseph S.
AU - Dalen, James E.
N1 - Funding Information:
The prognostic significance of atrial fibrillation complicating acute myocardial infarction remains controversial. Some studies 1-4 have found atrial fibrillation (AF) to affect the in-hospital survival of patients with acute myocardial infarction (MI) adversely, whereas other studies 5-9 have not arrived at this conclusion. Similarly, the impact of AF on the long-term survival of hospital survivors of acute MI remains From the Department of Medicine, Universityo f Massachusetts Medical School. Support for this project was providedb y NationalH eart, Lung,a nd Blood Institute grant No. R01 35434. Received for publication Aug. 14, 1989; accepted Dec. 20, 1989. Reprint requests: Robert J. Goldberg, PhD, Dept. of Medicine,U niversity of MassachusettsM edicalS chool, Worcester,M A 01655.
PY - 1990/5
Y1 - 1990/5
N2 - As part of an ongoing community-wide study examining changes over time in the incidence and survival rates of 4108 patients hospitalized with validated acute myocardial infarction (MI) in 16 hospitals in the Worcester, Massachusetts, metropolitan area during calendar years 1975, 1978, 1981, 1984, and 1986, we examined changes over time in the proportion of patients with acute MI developing atrial fibrillation (AF) and the impact of AF on in-hospital and long-term survival for up to a 10-year follow-up period. The overall percentage of patients with AF complicating acute MI was 16.0%; this proportion increased over time from 13.3% in 1975 to 14.8% in 1978, 14.9% in 1981, 20.3% in 1984, and to 17.7% in 1986. Patients with AF experienced consistently higher in-hospital case fatality rates than MI patients without AF overall (27.6% versus 16.6%), as well as during each of the 5 years under study. The independent effect of AF on in-hospital survival was not upheld, however, when a variety of potentially confounding prognostic factors were controlled for in a multivariate analysis resulting in an adjusted odds ratio (OR) of 1.18 (95% confidence interval 0.90, 1.52). Among discharged hospital patients, while the crude long-term survival rate for patients with AF was poorer than that of patients without AF for the combined as well as for individual study periods, similar to the in-hospital findings the independent effect of AF on long-term prognosis was not upheld after use of a multivariate analysis. The adjusted risk of dying over the 10-year follow-up period for discharged hospital survivors of AF was essentially similar to that for MI patients without AF (adjusted OR=1.04 (95% confidence interval, 0.87, 1.24). The results of this population-based study suggest that AF is a common complication of acute MI and that its potential impact on in-hospital and long-term survival may be mediated through other factors although it remains a marker of underlying ventricular dysfunction and a compromised myocardium.
AB - As part of an ongoing community-wide study examining changes over time in the incidence and survival rates of 4108 patients hospitalized with validated acute myocardial infarction (MI) in 16 hospitals in the Worcester, Massachusetts, metropolitan area during calendar years 1975, 1978, 1981, 1984, and 1986, we examined changes over time in the proportion of patients with acute MI developing atrial fibrillation (AF) and the impact of AF on in-hospital and long-term survival for up to a 10-year follow-up period. The overall percentage of patients with AF complicating acute MI was 16.0%; this proportion increased over time from 13.3% in 1975 to 14.8% in 1978, 14.9% in 1981, 20.3% in 1984, and to 17.7% in 1986. Patients with AF experienced consistently higher in-hospital case fatality rates than MI patients without AF overall (27.6% versus 16.6%), as well as during each of the 5 years under study. The independent effect of AF on in-hospital survival was not upheld, however, when a variety of potentially confounding prognostic factors were controlled for in a multivariate analysis resulting in an adjusted odds ratio (OR) of 1.18 (95% confidence interval 0.90, 1.52). Among discharged hospital patients, while the crude long-term survival rate for patients with AF was poorer than that of patients without AF for the combined as well as for individual study periods, similar to the in-hospital findings the independent effect of AF on long-term prognosis was not upheld after use of a multivariate analysis. The adjusted risk of dying over the 10-year follow-up period for discharged hospital survivors of AF was essentially similar to that for MI patients without AF (adjusted OR=1.04 (95% confidence interval, 0.87, 1.24). The results of this population-based study suggest that AF is a common complication of acute MI and that its potential impact on in-hospital and long-term survival may be mediated through other factors although it remains a marker of underlying ventricular dysfunction and a compromised myocardium.
UR - http://www.scopus.com/inward/record.url?scp=0025234506&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025234506&partnerID=8YFLogxK
U2 - 10.1016/S0002-8703(05)80227-3
DO - 10.1016/S0002-8703(05)80227-3
M3 - Article
C2 - 2330889
AN - SCOPUS:0025234506
VL - 119
SP - 996
EP - 1001
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 5
ER -