Immunotoxicity of poly-drug use: abnormalities in the active and high-affinity CD2 antigen (E-rosette receptor) bearing T-lymphocytes

Bindu S. Nair; Julie R. Erickson; Radhakrishna Pillai; Antonio Estrada; Ronald Ross Watson

doi:10.1016/0378-4274(91)90208-N

Immunotoxicity of poly-drug use: abnormalities in the active and high-affinity CD2 antigen (E-rosette receptor) bearing T-lymphocytes

Bindu S. Nair, Julie R. Erickson, Radhakrishna Pillai, Antonio Estrada, Ronald Ross Watson

Research output: Contribution to journal › Article › peer-review

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Abstract

The E-rosetting profiles of T-cells were studied in 47 subjects with a history of poly-drug and alcohol abuse, and compared with 15 normal controls. No change was evident in numbers of total rosette-forming cells (TRFC). However, there was reduction in active and high-affinity rosette-forming cells (ARFC and HARFC). These two subsets of CD2-antigen-bearing T-cells are considered as immunocompetent surveillance cells. Thus the abnormality associated with them could be due to the combined immunotoxic effects of substance abuse, modulating the immune status of drug users.

Original language	English (US)
Pages (from-to)	339-345
Number of pages	7
Journal	Toxicology letters
Volume	57
Issue number	3
DOIs	https://doi.org/10.1016/0378-4274(91)90208-N
State	Published - Aug 1991

Keywords

Immunotoxicity
Poly-drug abuse
T-cell

ASJC Scopus subject areas

Toxicology

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10.1016/0378-4274(91)90208-N

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title = "Immunotoxicity of poly-drug use: abnormalities in the active and high-affinity CD2 antigen (E-rosette receptor) bearing T-lymphocytes",

abstract = "The E-rosetting profiles of T-cells were studied in 47 subjects with a history of poly-drug and alcohol abuse, and compared with 15 normal controls. No change was evident in numbers of total rosette-forming cells (TRFC). However, there was reduction in active and high-affinity rosette-forming cells (ARFC and HARFC). These two subsets of CD2-antigen-bearing T-cells are considered as immunocompetent surveillance cells. Thus the abnormality associated with them could be due to the combined immunotoxic effects of substance abuse, modulating the immune status of drug users.",

keywords = "Immunotoxicity, Poly-drug abuse, T-cell",

author = "Nair, {Bindu S.} and Erickson, {Julie R.} and Radhakrishna Pillai and Antonio Estrada and Watson, {Ronald Ross}",

note = "Funding Information: The authorsa re gratefult o Rigoberto Centeno, M.D. and Gloria Venezuelaf or patient recruitmenta nd interview.T he secretariaal ssistanceo f Carol Burke is appreciated.S upportedb y NIDA Grant No. RI8 DA05748 and DA 04827a nd by NIAAA Grant No. 08037.",

year = "1991",

month = aug,

doi = "10.1016/0378-4274(91)90208-N",

language = "English (US)",

volume = "57",

pages = "339--345",

journal = "Toxicology letters",

issn = "0378-4274",

publisher = "Elsevier Ireland Ltd",

number = "3",

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T1 - Immunotoxicity of poly-drug use

T2 - abnormalities in the active and high-affinity CD2 antigen (E-rosette receptor) bearing T-lymphocytes

AU - Nair, Bindu S.

AU - Erickson, Julie R.

AU - Pillai, Radhakrishna

AU - Estrada, Antonio

AU - Watson, Ronald Ross

N1 - Funding Information: The authorsa re gratefult o Rigoberto Centeno, M.D. and Gloria Venezuelaf or patient recruitmenta nd interview.T he secretariaal ssistanceo f Carol Burke is appreciated.S upportedb y NIDA Grant No. RI8 DA05748 and DA 04827a nd by NIAAA Grant No. 08037.

PY - 1991/8

Y1 - 1991/8

N2 - The E-rosetting profiles of T-cells were studied in 47 subjects with a history of poly-drug and alcohol abuse, and compared with 15 normal controls. No change was evident in numbers of total rosette-forming cells (TRFC). However, there was reduction in active and high-affinity rosette-forming cells (ARFC and HARFC). These two subsets of CD2-antigen-bearing T-cells are considered as immunocompetent surveillance cells. Thus the abnormality associated with them could be due to the combined immunotoxic effects of substance abuse, modulating the immune status of drug users.

AB - The E-rosetting profiles of T-cells were studied in 47 subjects with a history of poly-drug and alcohol abuse, and compared with 15 normal controls. No change was evident in numbers of total rosette-forming cells (TRFC). However, there was reduction in active and high-affinity rosette-forming cells (ARFC and HARFC). These two subsets of CD2-antigen-bearing T-cells are considered as immunocompetent surveillance cells. Thus the abnormality associated with them could be due to the combined immunotoxic effects of substance abuse, modulating the immune status of drug users.

KW - Immunotoxicity

KW - Poly-drug abuse

KW - T-cell

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SN - 0378-4274

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ER -

Immunotoxicity of poly-drug use: abnormalities in the active and high-affinity CD2 antigen (E-rosette receptor) bearing T-lymphocytes

Abstract

Keywords

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