Immunosuppression with cyclophosphamide in the dog

C. W. Putnam; C. G. Halgrimson; C. G. Groth; N. Kashiwagi; K. A. Porter; T. E. Starzl

Immunosuppression with cyclophosphamide in the dog

C. W. Putnam, C. G. Halgrimson, C. G. Groth, N. Kashiwagi, K. A. Porter, T. E. Starzl

Research output: Contribution to journal › Article › peer-review

Abstract

Cyclophosphamide significantly diminished the canine humoral antibody response to sheep red blood cells and tended to prevent arterial lesions in renal homografts. However, cyclophosphamide failed to prolong renal homograft survival when administered to dogs as the sole immunosuppressive agent, and it did not add to the effectiveness of azathioprine when given as a supplement to the azathioprine and administered simultaneously or sequentially.

Original language	English (US)
Pages (from-to)	323-329
Number of pages	7
Journal	Clinical and Experimental Immunology
Volume	22
Issue number	2
State	Published - 1975
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Cite this

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title = "Immunosuppression with cyclophosphamide in the dog",

abstract = "Cyclophosphamide significantly diminished the canine humoral antibody response to sheep red blood cells and tended to prevent arterial lesions in renal homografts. However, cyclophosphamide failed to prolong renal homograft survival when administered to dogs as the sole immunosuppressive agent, and it did not add to the effectiveness of azathioprine when given as a supplement to the azathioprine and administered simultaneously or sequentially.",

author = "Putnam, {C. W.} and Halgrimson, {C. G.} and Groth, {C. G.} and N. Kashiwagi and Porter, {K. A.} and Starzl, {T. E.}",

year = "1975",

language = "English (US)",

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AU - Halgrimson, C. G.

AU - Groth, C. G.

AU - Kashiwagi, N.

AU - Porter, K. A.

AU - Starzl, T. E.

PY - 1975

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N2 - Cyclophosphamide significantly diminished the canine humoral antibody response to sheep red blood cells and tended to prevent arterial lesions in renal homografts. However, cyclophosphamide failed to prolong renal homograft survival when administered to dogs as the sole immunosuppressive agent, and it did not add to the effectiveness of azathioprine when given as a supplement to the azathioprine and administered simultaneously or sequentially.

AB - Cyclophosphamide significantly diminished the canine humoral antibody response to sheep red blood cells and tended to prevent arterial lesions in renal homografts. However, cyclophosphamide failed to prolong renal homograft survival when administered to dogs as the sole immunosuppressive agent, and it did not add to the effectiveness of azathioprine when given as a supplement to the azathioprine and administered simultaneously or sequentially.

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Immunosuppression with cyclophosphamide in the dog

Abstract

ASJC Scopus subject areas

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