Immunoquantitation of factor VIII-related antigen (Von Willebrand factor antigen) in prostate cancer

Richard J. Ablin, John M. Bartkus, Maurice J. Gonder

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Metastasization may be associated with activation of haemostatic processes resulting in increased levels of circulating factor VIII-related antigen (FVIIIRAg) (von Willebrand factor antigen). To evaluate the relevancy of this in prostate cancer (PCa), the level of FVIIIRAg in the serum of patients with PCa, benign prostatic hypertrophy (BPH) and non-prostatic diseases was quantitated by a modified micro enzyme-linked immunosorbent assay. Significant (P < 0.05) differences were noted between the level of FVIIRAg in PCa and patients with BPH and other than prostatic disease. Noteworthy were elevated levels of FVIIRAg in PAa patients with metastatic vs. localized disease. Consideration of the "unorthodox", but possibly more convenient use of routine serum specimens commonly available in the non-haematological laboratory vs. plasma for the quantitation of FVIIRAg, in situations where an "absolute" level is not required, and of disseminated intravascular coagulation as contributory to the present observations, is given. Pending evaluation of a larger patient population these observations may be of prognostic value.

Original languageEnglish (US)
Pages (from-to)283-289
Number of pages7
JournalCancer Letters
Volume40
Issue number3
DOIs
StatePublished - Jun 30 1988
Externally publishedYes

Keywords

  • Benign prostatic hypertrophy
  • Enzyme-linked immunosorbent assay
  • Factor VIII-related antigen
  • Prostate cancer
  • von Willebrand disease factor-related antigen
  • von Willebrand factor antigen

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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