Immunopathology of human T cell responses to skin, artery and endothelial cell grafts in the human peripheral blood lymphocyte/severe combined immunodeficient mouse

Jordan S. Pober, Alfred L.M. Bothwell, Marc I. Lorber, Jennifer M. McNiff, Jeffrey S. Schechner, George Tellides

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Blood vessels and their endothelial lining are major stimulators and targets of the rejection response. The immunological properties of human endothelial cells differ significantly from those of other species and new models are needed for proper study of human vessels in the transplant setting. We have employed the human peripheral blood lymphocyte/severe combined immunodeficiency (huPBL/SCID) mouse for this purpose. We describe here our results involving transplantation of human skin, human artery and cultured human endothelial cells. We also describe our more limited experience using porcine skin and artery transplantation to study human T cells responses to pig endothelium.

Original languageEnglish (US)
Pages (from-to)167-180
Number of pages14
JournalSpringer Seminars in Immunopathology
Volume25
Issue number2
DOIs
StatePublished - Sep 2003
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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