Immunopathology and immunotherapy of hodgkin lymphoma

Immunotherapy has led to promising results in the treatment of malignancies in recent decades. In view of the suboptimal results obtained by applying other treatment modalities in the treatment of Hodgkin lymphoma (HL), attention has been drawn to immunotherapy as an efficient alternative or complement therapy. This chapter seeks to discuss a wide spectrum of immunotherapeutic approaches, from initial monoclonal antibodies to novel techniques developed in recent years, which are still at their infancy. Since correct understanding of the underlying immunopathology seems inevitable in efficient immunotherapy and the development of future techniques, a brief description with the emphasis on suitable targets for immunotherapy is given before discussing various immunotherapies.