TY - JOUR
T1 - Immunopathogenesis of sarcoidosis
AU - Noor, Aliya
AU - Knox, Kenneth S.
N1 - Funding Information:
This study is partially supported by grants from the National Institutes of Health, Health Future Foundation, and Hunan Normal University and by a student tuition waiver to W.-M. Chen from Creighton University.
PY - 2007/5
Y1 - 2007/5
N2 - The immunopathogenesis of sarcoidosis has been difficult to charaterize given the heterogeneity of disease, the elusiveness of the causative antigen, and the lack of an adequate animal model. However, by examining well-defined clinical cohorts, the interplay between genetic predisposition and immunologic response has been increasingly informative. Technological advances in cellular analysis have allowed researchers to characterize the immune responses important in the maintenance of granulomatous inflammation. Finally, "new" clinical observations such as granuloma responsiveness to targeted biological therapies, sarcoid developing during immune restoration, and the relationship between sarcoidosis and Hepatitis C will provide future insight to the immunopathogenesis of sarcoidosis.
AB - The immunopathogenesis of sarcoidosis has been difficult to charaterize given the heterogeneity of disease, the elusiveness of the causative antigen, and the lack of an adequate animal model. However, by examining well-defined clinical cohorts, the interplay between genetic predisposition and immunologic response has been increasingly informative. Technological advances in cellular analysis have allowed researchers to characterize the immune responses important in the maintenance of granulomatous inflammation. Finally, "new" clinical observations such as granuloma responsiveness to targeted biological therapies, sarcoid developing during immune restoration, and the relationship between sarcoidosis and Hepatitis C will provide future insight to the immunopathogenesis of sarcoidosis.
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U2 - 10.1016/j.clindermatol.2007.03.002
DO - 10.1016/j.clindermatol.2007.03.002
M3 - Article
C2 - 17560302
AN - SCOPUS:34249788996
SN - 0738-081X
VL - 25
SP - 250
EP - 258
JO - Clinics in Dermatology
JF - Clinics in Dermatology
IS - 3
ER -