Immunomodulation by pycnogenol® in retrovirus-infected or ethanol-fed mice

Jeanne E. Cheshier; Sussan Ardestani-Kaboudanian; Bailin Liang; Mohsen Araghiniknam; Sangbun Chung; Lisa Lane; Anabell Castro; Ronald R. Watson

doi:10.1016/0024-3205(95)02303-8

Immunomodulation by pycnogenol® in retrovirus-infected or ethanol-fed mice

Jeanne E. Cheshier, Sussan Ardestani-Kaboudanian, Bailin Liang, Mohsen Araghiniknam, Sangbun Chung, Lisa Lane, Anabell Castro, Ronald R. Watson

Health Promotion Sciences

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Pycnogenol^® is a commercial mixture of bioflavonoids that exhibits antioxidative activity. The effects of dietary pycnogenol on immune dysfunction in normal mice as well as those fed ethanol or infected with the LP-BM5 murine retrovirus were determined. The ethanol consumption and retrovirus infection cause abnormalities in the function and/or structure of a broad array of cells involved in humoral and cellular immunity. Pycnogenol enhanced in vitro IL-2 production by mitogen-stimulated splenocytes if its production was suppressed in ethanolfed or retrovirus-infected mice. Mitogenesis of splenocytes did not show a significant change in mice treated with pycnogenol. It reduced the elevated levels of interleukin-6 produced in vitro by cells from retrovirus infected mice and IL-10 secreted by spleen cells from mice consuming ethanol. Natural killer cell cytotoxicity was increased with pycnogenol treatment.

Original language	English (US)
Pages (from-to)	PL87-PL96
Journal	Life Sciences
Volume	58
Issue number	5
DOIs	https://doi.org/10.1016/0024-3205(95)02303-8
State	Published - Dec 22 1995

Keywords

ethanol-fed mice
immune dysfunction
pycnogenol
retrovirus-infected mice

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(95)02303-8

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title = "Immunomodulation by pycnogenol{\textregistered} in retrovirus-infected or ethanol-fed mice",

abstract = "Pycnogenol{\textregistered} is a commercial mixture of bioflavonoids that exhibits antioxidative activity. The effects of dietary pycnogenol on immune dysfunction in normal mice as well as those fed ethanol or infected with the LP-BM5 murine retrovirus were determined. The ethanol consumption and retrovirus infection cause abnormalities in the function and/or structure of a broad array of cells involved in humoral and cellular immunity. Pycnogenol enhanced in vitro IL-2 production by mitogen-stimulated splenocytes if its production was suppressed in ethanolfed or retrovirus-infected mice. Mitogenesis of splenocytes did not show a significant change in mice treated with pycnogenol. It reduced the elevated levels of interleukin-6 produced in vitro by cells from retrovirus infected mice and IL-10 secreted by spleen cells from mice consuming ethanol. Natural killer cell cytotoxicity was increased with pycnogenol treatment.",

keywords = "ethanol-fed mice, immune dysfunction, pycnogenol, retrovirus-infected mice",

author = "Cheshier, {Jeanne E.} and Sussan Ardestani-Kaboudanian and Bailin Liang and Mohsen Araghiniknam and Sangbun Chung and Lisa Lane and Anabell Castro and Watson, {Ronald R.}",

year = "1995",

month = dec,

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doi = "10.1016/0024-3205(95)02303-8",

language = "English (US)",

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T1 - Immunomodulation by pycnogenol® in retrovirus-infected or ethanol-fed mice

AU - Cheshier, Jeanne E.

AU - Ardestani-Kaboudanian, Sussan

AU - Liang, Bailin

AU - Araghiniknam, Mohsen

AU - Chung, Sangbun

AU - Lane, Lisa

AU - Castro, Anabell

AU - Watson, Ronald R.

PY - 1995/12/22

Y1 - 1995/12/22

N2 - Pycnogenol® is a commercial mixture of bioflavonoids that exhibits antioxidative activity. The effects of dietary pycnogenol on immune dysfunction in normal mice as well as those fed ethanol or infected with the LP-BM5 murine retrovirus were determined. The ethanol consumption and retrovirus infection cause abnormalities in the function and/or structure of a broad array of cells involved in humoral and cellular immunity. Pycnogenol enhanced in vitro IL-2 production by mitogen-stimulated splenocytes if its production was suppressed in ethanolfed or retrovirus-infected mice. Mitogenesis of splenocytes did not show a significant change in mice treated with pycnogenol. It reduced the elevated levels of interleukin-6 produced in vitro by cells from retrovirus infected mice and IL-10 secreted by spleen cells from mice consuming ethanol. Natural killer cell cytotoxicity was increased with pycnogenol treatment.

AB - Pycnogenol® is a commercial mixture of bioflavonoids that exhibits antioxidative activity. The effects of dietary pycnogenol on immune dysfunction in normal mice as well as those fed ethanol or infected with the LP-BM5 murine retrovirus were determined. The ethanol consumption and retrovirus infection cause abnormalities in the function and/or structure of a broad array of cells involved in humoral and cellular immunity. Pycnogenol enhanced in vitro IL-2 production by mitogen-stimulated splenocytes if its production was suppressed in ethanolfed or retrovirus-infected mice. Mitogenesis of splenocytes did not show a significant change in mice treated with pycnogenol. It reduced the elevated levels of interleukin-6 produced in vitro by cells from retrovirus infected mice and IL-10 secreted by spleen cells from mice consuming ethanol. Natural killer cell cytotoxicity was increased with pycnogenol treatment.

KW - ethanol-fed mice

KW - immune dysfunction

KW - pycnogenol

KW - retrovirus-infected mice

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VL - 58

SP - PL87-PL96

JO - Life Sciences

JF - Life Sciences

IS - 5

ER -

Immunomodulation by pycnogenol® in retrovirus-infected or ethanol-fed mice

Abstract

Keywords

ASJC Scopus subject areas

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