Immunomodulation by pycnogenol® in retrovirus-infected or ethanol-fed mice

Jeanne E. Cheshier, Sussan Ardestani-Kaboudanian, Bailin Liang, Mohsen Araghiniknam, Sangbun Chung, Lisa Lane, Anabell Castro, Ronald R. Watson

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Pycnogenol® is a commercial mixture of bioflavonoids that exhibits antioxidative activity. The effects of dietary pycnogenol on immune dysfunction in normal mice as well as those fed ethanol or infected with the LP-BM5 murine retrovirus were determined. The ethanol consumption and retrovirus infection cause abnormalities in the function and/or structure of a broad array of cells involved in humoral and cellular immunity. Pycnogenol enhanced in vitro IL-2 production by mitogen-stimulated splenocytes if its production was suppressed in ethanolfed or retrovirus-infected mice. Mitogenesis of splenocytes did not show a significant change in mice treated with pycnogenol. It reduced the elevated levels of interleukin-6 produced in vitro by cells from retrovirus infected mice and IL-10 secreted by spleen cells from mice consuming ethanol. Natural killer cell cytotoxicity was increased with pycnogenol treatment.

Original languageEnglish (US)
Pages (from-to)PL87-PL96
JournalLife Sciences
Issue number5
StatePublished - Dec 22 1995


  • ethanol-fed mice
  • immune dysfunction
  • pycnogenol
  • retrovirus-infected mice

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


Dive into the research topics of 'Immunomodulation by pycnogenol® in retrovirus-infected or ethanol-fed mice'. Together they form a unique fingerprint.

Cite this