Immunometabolism: An Emerging Target for Immunotherapies to Treat Rheumatoid Arthritis

Joslyn L. Mangal; Neha Basu; Hsin Jung Joyce Wu; Abhinav P. Acharya

doi:10.20900/immunometab20210032

Immunometabolism: An Emerging Target for Immunotherapies to Treat Rheumatoid Arthritis

Joslyn L. Mangal, Neha Basu, Hsin Jung Joyce Wu, Abhinav P. Acharya

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

Abstract

An increasing number of findings highlight the fundamental role of metabolism in autoimmunity. This growing recognition of metabolic irregularities being a factor of immune dysregulation in autoimmunity has provided novel therapeutic opportunities. Although there have been advancements in the field of immunometabolism, it is important to note that strategies to engineer the immune system can also be utilized to modulate immunometabolism of specific immune cells that are involved in autoimmune rheumatoid arthritis (RA). Herein, we review the metabolic heterogeneity within RA, and discuss the potential therapies based on immunometabolism and immunoengineering concepts that may reinstate immune tolerance by targeting the metabolic irregularity within specific immune cells involved in the pathogenesis of RA.

Original language	English (US)
Article number	e210032
Journal	Immunometabolism (United States)
Volume	3
Issue number	4
DOIs	https://doi.org/10.20900/immunometab20210032
State	Published - Oct 21 2021
Externally published	Yes

Keywords

autoimmunity
immunoengineering
immunometabolism
rheumatoid arthritis

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Immunology and Allergy

Access to Document

10.20900/immunometab20210032

Cite this

@article{ab8f7f96ddcb4ad48bc8e3886907dfb7,

title = "Immunometabolism: An Emerging Target for Immunotherapies to Treat Rheumatoid Arthritis",

abstract = "An increasing number of findings highlight the fundamental role of metabolism in autoimmunity. This growing recognition of metabolic irregularities being a factor of immune dysregulation in autoimmunity has provided novel therapeutic opportunities. Although there have been advancements in the field of immunometabolism, it is important to note that strategies to engineer the immune system can also be utilized to modulate immunometabolism of specific immune cells that are involved in autoimmune rheumatoid arthritis (RA). Herein, we review the metabolic heterogeneity within RA, and discuss the potential therapies based on immunometabolism and immunoengineering concepts that may reinstate immune tolerance by targeting the metabolic irregularity within specific immune cells involved in the pathogenesis of RA.",

keywords = "autoimmunity, immunoengineering, immunometabolism, rheumatoid arthritis",

author = "Mangal, {Joslyn L.} and Neha Basu and Wu, {Hsin Jung Joyce} and Acharya, {Abhinav P.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2021 by the author(s). Licensee Hapres, London, United Kingdom.",

year = "2021",

month = oct,

day = "21",

doi = "10.20900/immunometab20210032",

language = "English (US)",

volume = "3",

journal = "Immunometabolism (United States)",

issn = "2633-0407",

publisher = "Lippincott Williams and Wilkins",

number = "4",

}

TY - JOUR

T1 - Immunometabolism

T2 - An Emerging Target for Immunotherapies to Treat Rheumatoid Arthritis

AU - Mangal, Joslyn L.

AU - Basu, Neha

AU - Wu, Hsin Jung Joyce

AU - Acharya, Abhinav P.

PY - 2021/10/21

Y1 - 2021/10/21

N2 - An increasing number of findings highlight the fundamental role of metabolism in autoimmunity. This growing recognition of metabolic irregularities being a factor of immune dysregulation in autoimmunity has provided novel therapeutic opportunities. Although there have been advancements in the field of immunometabolism, it is important to note that strategies to engineer the immune system can also be utilized to modulate immunometabolism of specific immune cells that are involved in autoimmune rheumatoid arthritis (RA). Herein, we review the metabolic heterogeneity within RA, and discuss the potential therapies based on immunometabolism and immunoengineering concepts that may reinstate immune tolerance by targeting the metabolic irregularity within specific immune cells involved in the pathogenesis of RA.

AB - An increasing number of findings highlight the fundamental role of metabolism in autoimmunity. This growing recognition of metabolic irregularities being a factor of immune dysregulation in autoimmunity has provided novel therapeutic opportunities. Although there have been advancements in the field of immunometabolism, it is important to note that strategies to engineer the immune system can also be utilized to modulate immunometabolism of specific immune cells that are involved in autoimmune rheumatoid arthritis (RA). Herein, we review the metabolic heterogeneity within RA, and discuss the potential therapies based on immunometabolism and immunoengineering concepts that may reinstate immune tolerance by targeting the metabolic irregularity within specific immune cells involved in the pathogenesis of RA.

KW - autoimmunity

KW - immunoengineering

KW - immunometabolism

KW - rheumatoid arthritis

UR - http://www.scopus.com/inward/record.url?scp=85188180951&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85188180951&partnerID=8YFLogxK

U2 - 10.20900/immunometab20210032

DO - 10.20900/immunometab20210032

M3 - Review article

AN - SCOPUS:85188180951

SN - 2633-0407

VL - 3

JO - Immunometabolism (United States)

JF - Immunometabolism (United States)

IS - 4

M1 - e210032

ER -

Immunometabolism: An Emerging Target for Immunotherapies to Treat Rheumatoid Arthritis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this