TY - JOUR
T1 - Immunological enhancement by fat-soluble vitamins, minerals, and trace metals
T2 - a factor in cancer prevention.
AU - Watson, R. R.
PY - 1986
Y1 - 1986
N2 - High intakes of some fat-soluble vitamin or trace metals have been associated with a decreased risk of cancer. A mechanism to help explain their anticancer action might be immunosuppression during deficiency or immuno-enhancement with high intakes. In vitro, retinol suppressed T-lymphocyte functions, whereas high dietary vitamin A enhanced macrophage functions. High intakes of vitamin E can enhance some anticancer, immune defenses. Selenium excess was not very suppressive of immune functions in vitro, but did retard tumor cell growth. Selenium and zinc deficiencies are associated with immunosuppression. Enhanced immune functions by high intakes of trace elements and vitamins provide a mechanism to explain in part the concomitant decreased cancer incidence.
AB - High intakes of some fat-soluble vitamin or trace metals have been associated with a decreased risk of cancer. A mechanism to help explain their anticancer action might be immunosuppression during deficiency or immuno-enhancement with high intakes. In vitro, retinol suppressed T-lymphocyte functions, whereas high dietary vitamin A enhanced macrophage functions. High intakes of vitamin E can enhance some anticancer, immune defenses. Selenium excess was not very suppressive of immune functions in vitro, but did retard tumor cell growth. Selenium and zinc deficiencies are associated with immunosuppression. Enhanced immune functions by high intakes of trace elements and vitamins provide a mechanism to explain in part the concomitant decreased cancer incidence.
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M3 - Article
C2 - 3731196
AN - SCOPUS:0022518912
SN - 0361-090X
VL - 9
SP - 67
EP - 77
JO - Cancer detection and prevention
JF - Cancer detection and prevention
IS - 1-2
ER -