TY - JOUR
T1 - Immunologic responses associated with 12 weeks of combination antiretroviral therapy consisting of Zidovudine, Lamivudine, and Ritonavir
T2 - Results of AIDS clinical trials group protocol 315
AU - Lederman, Michael M.
AU - Connick, Elizabeth
AU - Landay, Alan
AU - Kuritzkes, Daniel R.
AU - Spritzler, John
AU - Clair, Marty St
AU - Kotzin, Brian L.
AU - Fox, Lawrence
AU - Chiozzi, Margo Heath
AU - Leonard, John M.
AU - Rousseau, Franck
AU - Wade, Michael
AU - Roe, Joana D.Arc
AU - Martinez, Ana
AU - Kessler, Harold
PY - 1998
Y1 - 1998
N2 - Human immunodeficiency virus (HIV)-1 infection is associated with progressive cell-mediated immune deficiency and abnormal immune activation. Although highly active antiretroviral therapy regimens can increase circulating CD4 T lymphocyte counts and decrease the risk of opportunistic complications, the effects of these treatments on immune reconstitution are not well understood. In 44 persons with moderately advanced HIV-1 infection, after 12 weeks of treatment with zidovudine, lamivudine, and ritonavir, plasma HIV-1 RNA fell a median of 2.3 logs (P < .0001). Circulating numbers of naive and memory CD4 T lymphocytes (P < .001), naive CD8 T lymphocytes (P < .004), and B lymphocytes (P < .001) increased. Improved lymphocyte proliferation to certain antigens and a tendency to improvement in delayed- type hypersensitivity also were seen. Dysregulated immune activation was partially corrected by this regimen; however, the perturbed expression of T cell receptor V regions in the CD4 and CD8 T lymphocyte population was not significantly affected. Ongoing studies will ascertain if longer durations of virus suppression will permit more complete immune restoration.
AB - Human immunodeficiency virus (HIV)-1 infection is associated with progressive cell-mediated immune deficiency and abnormal immune activation. Although highly active antiretroviral therapy regimens can increase circulating CD4 T lymphocyte counts and decrease the risk of opportunistic complications, the effects of these treatments on immune reconstitution are not well understood. In 44 persons with moderately advanced HIV-1 infection, after 12 weeks of treatment with zidovudine, lamivudine, and ritonavir, plasma HIV-1 RNA fell a median of 2.3 logs (P < .0001). Circulating numbers of naive and memory CD4 T lymphocytes (P < .001), naive CD8 T lymphocytes (P < .004), and B lymphocytes (P < .001) increased. Improved lymphocyte proliferation to certain antigens and a tendency to improvement in delayed- type hypersensitivity also were seen. Dysregulated immune activation was partially corrected by this regimen; however, the perturbed expression of T cell receptor V regions in the CD4 and CD8 T lymphocyte population was not significantly affected. Ongoing studies will ascertain if longer durations of virus suppression will permit more complete immune restoration.
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U2 - 10.1086/515591
DO - 10.1086/515591
M3 - Article
C2 - 9652425
AN - SCOPUS:17344365057
VL - 178
SP - 70
EP - 79
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 1
ER -