Immunologic and morphologic effects of cryosurgery of the monkey (Macaque) prostate

Krishna P. Reddy, Richard J. Ablin

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


A reduction in the size of the Macaque prostate following single and multiple in situ freezings was accompanied by histologic alterations, which occurred predominately in the caudal lobe and were characterized by what appeared to be specific periacinar foci of lymphocytic infiltrates. These lymphocytes were observed to infiltrate onto acinar epithelial cells, resulting in their subsequent separation from the basal lamina and epithelial destruction. Other histologic alterations were in consonance with studies of the prostate following cryosurgery by others. Circulating antibodies specific for prostate were present in only one of the seven animals at the time at which these histologic observations were made. These observations suggest the possible development of a cellular immunologic response following cryosurgery of the prostate. The relevancy of these observations to those obtained following cryoprostatectomy in man and other species is considered. Pending confirmation, they may be of potential significance in providing an explanation of reported cases of eradication of human prostatic carcinomas following cryotherapy.

Original languageEnglish (US)
Pages (from-to)123-138
Number of pages16
JournalResearch in Experimental Medicine
Issue number2
StatePublished - Jun 1979
Externally publishedYes


  • Cellular response
  • Cryosurgery
  • Histopathology
  • Humoral response
  • Monkey (Macaque)
  • Prostate

ASJC Scopus subject areas

  • General Medicine


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