Immunolocalization of two cytochrome P450 isozymes in rat nasal chemosensory tissue

Ying Chen; Marilyn L. Getchell; Xinxin Ding; Thomas V. Getchell

doi:10.1097/00001756-199209000-00007

Immunolocalization of two cytochrome P450 isozymes in rat nasal chemosensory tissue

Ying Chen, Marilyn L. Getchell, Xinxin Ding, Thomas V. Getchell

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

The NMa and NMb isoforms of cytochrome P450 enzymes are expressed in three nasal chemosensory organs: the olfactory, septal and vomeronasal mucosae. The NMa isoform is widely distributed throughout the nasal mucosa whereas the NMb isoform is present primarily in the chemosensory mucosae. The localization of cytochromes P450 demonstrates that sustentacular cells in the olfactory and septal epithelia, the mucus of the vomeronasal organ and the acinar cells of glands in the lamina propria of all three chemosensory systems engage in xenobiotic metabolism and participate in odorant/ pheromone clearance, a perireceptor process associated with chemosensory transduction.

Original language	English (US)
Pages (from-to)	749-752
Number of pages	4
Journal	NeuroReport
Volume	3
Issue number	9
DOIs	https://doi.org/10.1097/00001756-199209000-00007
State	Published - Sep 1992

Keywords

NMa
NMb
Olfactory mucosa
Perireceptor events
Phase I biotransformation enzymes
Septal organ of masera
Vomeronasal organ
Xenobiotic metabolism

ASJC Scopus subject areas

Neuroscience(all)

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10.1097/00001756-199209000-00007

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title = "Immunolocalization of two cytochrome P450 isozymes in rat nasal chemosensory tissue",

abstract = "The NMa and NMb isoforms of cytochrome P450 enzymes are expressed in three nasal chemosensory organs: the olfactory, septal and vomeronasal mucosae. The NMa isoform is widely distributed throughout the nasal mucosa whereas the NMb isoform is present primarily in the chemosensory mucosae. The localization of cytochromes P450 demonstrates that sustentacular cells in the olfactory and septal epithelia, the mucus of the vomeronasal organ and the acinar cells of glands in the lamina propria of all three chemosensory systems engage in xenobiotic metabolism and participate in odorant/ pheromone clearance, a perireceptor process associated with chemosensory transduction.",

keywords = "NMa, NMb, Olfactory mucosa, Perireceptor events, Phase I biotransformation enzymes, Septal organ of masera, Vomeronasal organ, Xenobiotic metabolism",

author = "Ying Chen and Getchell, {Marilyn L.} and Xinxin Ding and Getchell, {Thomas V.}",

year = "1992",

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T1 - Immunolocalization of two cytochrome P450 isozymes in rat nasal chemosensory tissue

AU - Chen, Ying

AU - Getchell, Marilyn L.

AU - Ding, Xinxin

AU - Getchell, Thomas V.

PY - 1992/9

Y1 - 1992/9

N2 - The NMa and NMb isoforms of cytochrome P450 enzymes are expressed in three nasal chemosensory organs: the olfactory, septal and vomeronasal mucosae. The NMa isoform is widely distributed throughout the nasal mucosa whereas the NMb isoform is present primarily in the chemosensory mucosae. The localization of cytochromes P450 demonstrates that sustentacular cells in the olfactory and septal epithelia, the mucus of the vomeronasal organ and the acinar cells of glands in the lamina propria of all three chemosensory systems engage in xenobiotic metabolism and participate in odorant/ pheromone clearance, a perireceptor process associated with chemosensory transduction.

AB - The NMa and NMb isoforms of cytochrome P450 enzymes are expressed in three nasal chemosensory organs: the olfactory, septal and vomeronasal mucosae. The NMa isoform is widely distributed throughout the nasal mucosa whereas the NMb isoform is present primarily in the chemosensory mucosae. The localization of cytochromes P450 demonstrates that sustentacular cells in the olfactory and septal epithelia, the mucus of the vomeronasal organ and the acinar cells of glands in the lamina propria of all three chemosensory systems engage in xenobiotic metabolism and participate in odorant/ pheromone clearance, a perireceptor process associated with chemosensory transduction.

KW - NMa

KW - NMb

KW - Olfactory mucosa

KW - Perireceptor events

KW - Phase I biotransformation enzymes

KW - Septal organ of masera

KW - Vomeronasal organ

KW - Xenobiotic metabolism

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JO - NeuroReport

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ER -

Immunolocalization of two cytochrome P450 isozymes in rat nasal chemosensory tissue

Abstract

Keywords

ASJC Scopus subject areas

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