Immunohistochemistry of the blood group A, B, H isoantigens and Oxford Ca antigen as prognostic markers for stage IB squamous cell carcinoma of the cervix

C. W. Alexander; Seng‐jaw ‐j Soong; Hugh M. Shingleton; Hazel Gore; James A. Wilkerson; Kenneth D. Hatch; Dale Phillips; James R. Dollar

doi:10.1002/1097-0142(19861201)58:11<2435::AID-CNCR2820581114>3.0.CO;2-N

Immunohistochemistry of the blood group A, B, H isoantigens and Oxford Ca antigen as prognostic markers for stage IB squamous cell carcinoma of the cervix

C. W. Alexander, Seng‐jaw ‐j Soong, Hugh M. Shingleton, Hazel Gore, James A. Wilkerson, Kenneth D. Hatch, Dale Phillips, James R. Dollar

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Currently, there is lack of a histologic classification of squamous cell carcinoma of the cervix that correlates significantly with patient survival. This study investigated the survival predictive value of two immuno‐histochemical markers, the blood group A,B,H isoantigens and the Oxford Ca antigen, on conventional histologic sections of tumor tissues from 85 surgically treated patients with Stage IB squamous cell cervical cancer. The results indicated that the two antigens are two distinct markers, neither of which correlates with tumor grade. The expression of the A,B,H isoantigens is significantly related to patient survival after adjustment for the depth of stromal invasion of the tumor, whereas the Oxford Ca antigen has no survival predictive value.

Original language	English (US)
Pages (from-to)	2435-2439
Number of pages	5
Journal	Cancer
Volume	58
Issue number	11
DOIs	https://doi.org/10.1002/1097-0142(19861201)58:11<2435::AID-CNCR2820581114>3.0.CO;2-N
State	Published - Dec 1 1986

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/1097-0142(19861201)58:11<2435::AID-CNCR2820581114>3.0.CO;2-N

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Alexander, C. W., Soong, S. ., Shingleton, H. M., Gore, H., Wilkerson, J. A., Hatch, K. D., Phillips, D., & Dollar, J. R. (1986). Immunohistochemistry of the blood group A, B, H isoantigens and Oxford Ca antigen as prognostic markers for stage IB squamous cell carcinoma of the cervix. Cancer, 58(11), 2435-2439. https://doi.org/10.1002/1097-0142(19861201)58:11<2435::AID-CNCR2820581114>3.0.CO;2-N

Immunohistochemistry of the blood group A, B, H isoantigens and Oxford Ca antigen as prognostic markers for stage IB squamous cell carcinoma of the cervix. / Alexander, C. W.; Soong, Seng‐jaw ‐j; Shingleton, Hugh M.; Gore, Hazel; Wilkerson, James A.; Hatch, Kenneth D.; Phillips, Dale; Dollar, James R.

In: Cancer, Vol. 58, No. 11, 01.12.1986, p. 2435-2439.

Research output: Contribution to journal › Article › peer-review

Alexander, CW, Soong, S, Shingleton, HM, Gore, H, Wilkerson, JA, Hatch, KD, Phillips, D & Dollar, JR 1986, 'Immunohistochemistry of the blood group A, B, H isoantigens and Oxford Ca antigen as prognostic markers for stage IB squamous cell carcinoma of the cervix', Cancer, vol. 58, no. 11, pp. 2435-2439. https://doi.org/10.1002/1097-0142(19861201)58:11<2435::AID-CNCR2820581114>3.0.CO;2-N

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abstract = "Currently, there is lack of a histologic classification of squamous cell carcinoma of the cervix that correlates significantly with patient survival. This study investigated the survival predictive value of two immuno‐histochemical markers, the blood group A,B,H isoantigens and the Oxford Ca antigen, on conventional histologic sections of tumor tissues from 85 surgically treated patients with Stage IB squamous cell cervical cancer. The results indicated that the two antigens are two distinct markers, neither of which correlates with tumor grade. The expression of the A,B,H isoantigens is significantly related to patient survival after adjustment for the depth of stromal invasion of the tumor, whereas the Oxford Ca antigen has no survival predictive value.",

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AB - Currently, there is lack of a histologic classification of squamous cell carcinoma of the cervix that correlates significantly with patient survival. This study investigated the survival predictive value of two immuno‐histochemical markers, the blood group A,B,H isoantigens and the Oxford Ca antigen, on conventional histologic sections of tumor tissues from 85 surgically treated patients with Stage IB squamous cell cervical cancer. The results indicated that the two antigens are two distinct markers, neither of which correlates with tumor grade. The expression of the A,B,H isoantigens is significantly related to patient survival after adjustment for the depth of stromal invasion of the tumor, whereas the Oxford Ca antigen has no survival predictive value.

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Immunohistochemistry of the blood group A, B, H isoantigens and Oxford Ca antigen as prognostic markers for stage IB squamous cell carcinoma of the cervix

Abstract

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