Immunocytochemical localization of a gastric inhibitory polypeptide‐like material within A‐cells of the endocrine pancreas

Phillip H. Smith; Frederick W. Merchant; David G. Johnson; Wilfred Y. Fujimoto; Robert H. Williams

doi:10.1002/aja.1001490410

Immunocytochemical localization of a gastric inhibitory polypeptide‐like material within A‐cells of the endocrine pancreas

Phillip H. Smith
, Frederick W. Merchant
, David G. Johnson
, Wilfred Y. Fujimoto
, Robert H. Williams

Medicine

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

In rat pancreatic islets, the glucagon‐producing A‐cells also contain a GIP‐like material as revealed by the peroxidaseantiperoxidase immunocytochemical technique. Control studies showed that this dual staining was not due to the cross‐reactivity of anti‐GIP with glucagon. It is concluded either that the A‐cells synthesize a GIP‐like peptide or that it is taken up from the circulation.

Original language	English (US)
Pages (from-to)	585-590
Number of pages	6
Journal	American Journal of Anatomy
Volume	149
Issue number	4
DOIs	https://doi.org/10.1002/aja.1001490410
State	Published - Aug 1977

ASJC Scopus subject areas

Anatomy

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10.1002/aja.1001490410

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title = "Immunocytochemical localization of a gastric inhibitory polypeptide‐like material within A‐cells of the endocrine pancreas",

abstract = "In rat pancreatic islets, the glucagon‐producing A‐cells also contain a GIP‐like material as revealed by the peroxidaseantiperoxidase immunocytochemical technique. Control studies showed that this dual staining was not due to the cross‐reactivity of anti‐GIP with glucagon. It is concluded either that the A‐cells synthesize a GIP‐like peptide or that it is taken up from the circulation.",

author = "Smith, \{Phillip H.\} and Merchant, \{Frederick W.\} and Johnson, \{David G.\} and Fujimoto, \{Wilfred Y.\} and Williams, \{Robert H.\}",

year = "1977",

month = aug,

doi = "10.1002/aja.1001490410",

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volume = "149",

pages = "585--590",

journal = "American Journal of Anatomy",

issn = "0002-9106",

publisher = "John Wiley \& Sons Inc.",

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T1 - Immunocytochemical localization of a gastric inhibitory polypeptide‐like material within A‐cells of the endocrine pancreas

AU - Smith, Phillip H.

AU - Merchant, Frederick W.

AU - Johnson, David G.

AU - Fujimoto, Wilfred Y.

AU - Williams, Robert H.

PY - 1977/8

Y1 - 1977/8

N2 - In rat pancreatic islets, the glucagon‐producing A‐cells also contain a GIP‐like material as revealed by the peroxidaseantiperoxidase immunocytochemical technique. Control studies showed that this dual staining was not due to the cross‐reactivity of anti‐GIP with glucagon. It is concluded either that the A‐cells synthesize a GIP‐like peptide or that it is taken up from the circulation.

AB - In rat pancreatic islets, the glucagon‐producing A‐cells also contain a GIP‐like material as revealed by the peroxidaseantiperoxidase immunocytochemical technique. Control studies showed that this dual staining was not due to the cross‐reactivity of anti‐GIP with glucagon. It is concluded either that the A‐cells synthesize a GIP‐like peptide or that it is taken up from the circulation.

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UR - https://www.scopus.com/pages/publications/0017694293#tab=citedBy

U2 - 10.1002/aja.1001490410

DO - 10.1002/aja.1001490410

M3 - Article

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AN - SCOPUS:0017694293

SN - 0002-9106

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SP - 585

EP - 590

JO - American Journal of Anatomy

JF - American Journal of Anatomy

IS - 4

ER -

Immunocytochemical localization of a gastric inhibitory polypeptide‐like material within A‐cells of the endocrine pancreas

Abstract

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