Immunocytochemical localization of a gastric inhibitory polypeptide‐like material within A‐cells of the endocrine pancreas

Phillip H. Smith; Frederick W. Merchant; David G. Johnson; Wilfred Y. Fujimoto; Robert H. Williams

doi:10.1002/aja.1001490410

Immunocytochemical localization of a gastric inhibitory polypeptide‐like material within A‐cells of the endocrine pancreas

Phillip H. Smith, Frederick W. Merchant, David G. Johnson, Wilfred Y. Fujimoto, Robert H. Williams

Medicine

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Abstract

In rat pancreatic islets, the glucagon‐producing A‐cells also contain a GIP‐like material as revealed by the peroxidaseantiperoxidase immunocytochemical technique. Control studies showed that this dual staining was not due to the cross‐reactivity of anti‐GIP with glucagon. It is concluded either that the A‐cells synthesize a GIP‐like peptide or that it is taken up from the circulation.

Original language	English (US)
Pages (from-to)	585-590
Number of pages	6
Journal	American Journal of Anatomy
Volume	149
Issue number	4
DOIs	https://doi.org/10.1002/aja.1001490410
State	Published - Aug 1977

ASJC Scopus subject areas

Anatomy

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title = "Immunocytochemical localization of a gastric inhibitory polypeptide‐like material within A‐cells of the endocrine pancreas",

abstract = "In rat pancreatic islets, the glucagon‐producing A‐cells also contain a GIP‐like material as revealed by the peroxidaseantiperoxidase immunocytochemical technique. Control studies showed that this dual staining was not due to the cross‐reactivity of anti‐GIP with glucagon. It is concluded either that the A‐cells synthesize a GIP‐like peptide or that it is taken up from the circulation.",

author = "Smith, {Phillip H.} and Merchant, {Frederick W.} and Johnson, {David G.} and Fujimoto, {Wilfred Y.} and Williams, {Robert H.}",

year = "1977",

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AU - Smith, Phillip H.

AU - Merchant, Frederick W.

AU - Johnson, David G.

AU - Fujimoto, Wilfred Y.

AU - Williams, Robert H.

PY - 1977/8

Y1 - 1977/8

N2 - In rat pancreatic islets, the glucagon‐producing A‐cells also contain a GIP‐like material as revealed by the peroxidaseantiperoxidase immunocytochemical technique. Control studies showed that this dual staining was not due to the cross‐reactivity of anti‐GIP with glucagon. It is concluded either that the A‐cells synthesize a GIP‐like peptide or that it is taken up from the circulation.

AB - In rat pancreatic islets, the glucagon‐producing A‐cells also contain a GIP‐like material as revealed by the peroxidaseantiperoxidase immunocytochemical technique. Control studies showed that this dual staining was not due to the cross‐reactivity of anti‐GIP with glucagon. It is concluded either that the A‐cells synthesize a GIP‐like peptide or that it is taken up from the circulation.

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Immunocytochemical localization of a gastric inhibitory polypeptide‐like material within A‐cells of the endocrine pancreas

Abstract

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