Immune responses to the pertussis toxin in Balb/c and C57B1/6 mice

J. M. Alonso; F. Megret; C. Brezin; R. L. Friedman; J. E. Alouf

doi:10.1111/j.1574-6968.1986.tb01689.x

Immune responses to the pertussis toxin in Balb/c and C57B1/6 mice

J. M. Alonso
, F. Megret
, C. Brezin
, R. L. Friedman
, J. E. Alouf

Immunobiology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Immunization of Balb/c and C57B1/6 mice with the pertussis toxin (Ptx), purified from the culture supernatant of Bordetella pertussis (the whooping cough bacillus) resulted in different immune reactions in these genetically different strains of mice. Antibody responses to Ptx were detected only in Balb/c, whereas both Balb/c and C57B1/6 produced anti-Ptx antibodies when immunized with detoxified Ptx. Also, delayed-type hypersensitivity reactions differ strongly according to the use of Ptx or detoxified Ptx as eliciting antigen.

Original language	English (US)
Pages (from-to)	167-171
Number of pages	5
Journal	FEMS Microbiology Letters
Volume	36
Issue number	2-3
DOIs	https://doi.org/10.1111/j.1574-6968.1986.tb01689.x
State	Published - Sep 1986

Keywords

Bordetella pertussis
immune response
pertussis toxin

ASJC Scopus subject areas

General Medicine

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10.1111/j.1574-6968.1986.tb01689.x

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title = "Immune responses to the pertussis toxin in Balb/c and C57B1/6 mice",

abstract = "Immunization of Balb/c and C57B1/6 mice with the pertussis toxin (Ptx), purified from the culture supernatant of Bordetella pertussis (the whooping cough bacillus) resulted in different immune reactions in these genetically different strains of mice. Antibody responses to Ptx were detected only in Balb/c, whereas both Balb/c and C57B1/6 produced anti-Ptx antibodies when immunized with detoxified Ptx. Also, delayed-type hypersensitivity reactions differ strongly according to the use of Ptx or detoxified Ptx as eliciting antigen.",

keywords = "Bordetella pertussis, immune response, pertussis toxin",

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year = "1986",

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T1 - Immune responses to the pertussis toxin in Balb/c and C57B1/6 mice

AU - Alonso, J. M.

AU - Megret, F.

AU - Brezin, C.

AU - Friedman, R. L.

AU - Alouf, J. E.

PY - 1986/9

Y1 - 1986/9

N2 - Immunization of Balb/c and C57B1/6 mice with the pertussis toxin (Ptx), purified from the culture supernatant of Bordetella pertussis (the whooping cough bacillus) resulted in different immune reactions in these genetically different strains of mice. Antibody responses to Ptx were detected only in Balb/c, whereas both Balb/c and C57B1/6 produced anti-Ptx antibodies when immunized with detoxified Ptx. Also, delayed-type hypersensitivity reactions differ strongly according to the use of Ptx or detoxified Ptx as eliciting antigen.

AB - Immunization of Balb/c and C57B1/6 mice with the pertussis toxin (Ptx), purified from the culture supernatant of Bordetella pertussis (the whooping cough bacillus) resulted in different immune reactions in these genetically different strains of mice. Antibody responses to Ptx were detected only in Balb/c, whereas both Balb/c and C57B1/6 produced anti-Ptx antibodies when immunized with detoxified Ptx. Also, delayed-type hypersensitivity reactions differ strongly according to the use of Ptx or detoxified Ptx as eliciting antigen.

KW - Bordetella pertussis

KW - immune response

KW - pertussis toxin

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JF - FEMS Microbiology Letters

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ER -

Immune responses to the pertussis toxin in Balb/c and C57B1/6 mice

Abstract

Keywords

ASJC Scopus subject areas

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