Immune responses to the pertussis toxin in Balb/c and C57B1/6 mice

J. M. Alonso, F. Megret, C. Brezin, R. L. Friedman, J. E. Alouf

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Immunization of Balb/c and C57B1/6 mice with the pertussis toxin (Ptx), purified from the culture supernatant of Bordetella pertussis (the whooping cough bacillus) resulted in different immune reactions in these genetically different strains of mice. Antibody responses to Ptx were detected only in Balb/c, whereas both Balb/c and C57B1/6 produced anti-Ptx antibodies when immunized with detoxified Ptx. Also, delayed-type hypersensitivity reactions differ strongly according to the use of Ptx or detoxified Ptx as eliciting antigen.

Original languageEnglish (US)
Pages (from-to)167-171
Number of pages5
JournalFEMS Microbiology Letters
Issue number2-3
StatePublished - Sep 1986


  • Bordetella pertussis
  • immune response
  • pertussis toxin

ASJC Scopus subject areas

  • General Medicine


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