Immune responses in the skin in old age

Milica Vukmanovic-Stejic; Malcolm H.A. Rustin; Janko Nikolich-Zugich; Arne N. Akbar

doi:10.1016/j.coi.2011.05.008

Immune responses in the skin in old age

Milica Vukmanovic-Stejic
, Malcolm H.A. Rustin
, Janko Nikolich-Zugich
, Arne N. Akbar

Research output: Contribution to journal › Review article › peer-review

52 Scopus citations

Abstract

A marked increase in the susceptibility to cutaneous infections and malignancies has been observed in older humans indicating that cutaneous immunity becomes defective with age. In this review we will focus on recent developments in the understanding of age-related changes in immune function of the skin with a particular emphasis on how alterations in the interaction between cells involved in innate and adaptive immunity leads to decreased cutaneous antigen-specific T cell immunosurveillance.

Original language	English (US)
Pages (from-to)	525-531
Number of pages	7
Journal	Current Opinion in Immunology
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/j.coi.2011.05.008
State	Published - Aug 2011

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.coi.2011.05.008

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@article{82b8b27a0e154bfc9e5cd10dcd3d573f,

title = "Immune responses in the skin in old age",

abstract = "A marked increase in the susceptibility to cutaneous infections and malignancies has been observed in older humans indicating that cutaneous immunity becomes defective with age. In this review we will focus on recent developments in the understanding of age-related changes in immune function of the skin with a particular emphasis on how alterations in the interaction between cells involved in innate and adaptive immunity leads to decreased cutaneous antigen-specific T cell immunosurveillance.",

author = "Milica Vukmanovic-Stejic and Rustin, \{Malcolm H.A.\} and Janko Nikolich-Zugich and Akbar, \{Arne N.\}",

note = "Funding Information: Authors would like to acknowledge support of the MRC UK (grant award G0901102 to MV-S), BBSRC, British Skin Foundation and Dermatrust (to AA) and National Institutes of Health (grant awards AG20719 and AG03319 , National Institute on Ageing to JN-{\v Z}). ",

year = "2011",

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doi = "10.1016/j.coi.2011.05.008",

language = "English (US)",

volume = "23",

pages = "525--531",

journal = "Current Opinion in Immunology",

issn = "0952-7915",

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T1 - Immune responses in the skin in old age

AU - Vukmanovic-Stejic, Milica

AU - Rustin, Malcolm H.A.

AU - Nikolich-Zugich, Janko

AU - Akbar, Arne N.

N1 - Funding Information: Authors would like to acknowledge support of the MRC UK (grant award G0901102 to MV-S), BBSRC, British Skin Foundation and Dermatrust (to AA) and National Institutes of Health (grant awards AG20719 and AG03319 , National Institute on Ageing to JN-Ž).

PY - 2011/8

Y1 - 2011/8

N2 - A marked increase in the susceptibility to cutaneous infections and malignancies has been observed in older humans indicating that cutaneous immunity becomes defective with age. In this review we will focus on recent developments in the understanding of age-related changes in immune function of the skin with a particular emphasis on how alterations in the interaction between cells involved in innate and adaptive immunity leads to decreased cutaneous antigen-specific T cell immunosurveillance.

AB - A marked increase in the susceptibility to cutaneous infections and malignancies has been observed in older humans indicating that cutaneous immunity becomes defective with age. In this review we will focus on recent developments in the understanding of age-related changes in immune function of the skin with a particular emphasis on how alterations in the interaction between cells involved in innate and adaptive immunity leads to decreased cutaneous antigen-specific T cell immunosurveillance.

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UR - https://www.scopus.com/pages/publications/80052354478#tab=citedBy

U2 - 10.1016/j.coi.2011.05.008

DO - 10.1016/j.coi.2011.05.008

M3 - Review article

C2 - 21703840

AN - SCOPUS:80052354478

SN - 0952-7915

VL - 23

SP - 525

EP - 531

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

IS - 4

ER -

Immune responses in the skin in old age

Abstract

ASJC Scopus subject areas

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