Immune protection against virus challenge in aging mice is not affected by latent herpesviral infections

Thomas F. Marandu; Jennifer D. Oduro; Lisa Borkner; Iryna Dekhtiarenko; Jennifer L. Uhrlaub; Anja Drabig; Andrea Kröger; Janko Nikolich-Zugich; Luka Cicin-Sain

doi:10.1128/JVI.01989-15

Immune protection against virus challenge in aging mice is not affected by latent herpesviral infections

Thomas F. Marandu, Jennifer D. Oduro, Lisa Borkner, Iryna Dekhtiarenko, Jennifer L. Uhrlaub, Anja Drabig, Andrea Kröger, Janko Nikolich-Zugich, Luka Cicin-Sain

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Latent herpesvirus infections alter immune homeostasis. To understand if this results in aging-related loss of immune protection against emerging infections, we challenged old mice carrying latent mouse cytomegalovirus (CMV), herpes simplex virus 1 (HSV-1), and/or murine gammaherpesvirus 68 (MHV-68) with influenza virus, West Nile virus (WNV), or vesicular stomatitis virus (VSV). We observed no increase in mortality or weight loss compared to results seen with herpesvirus-negative counterparts and a relative but not absolute reduction in CD8 responses to acute infections. Therefore, the presence of herpesviruses does not appear to increase susceptibility to emerging infections in aging patients.

Original language	English (US)
Pages (from-to)	11715-11717
Number of pages	3
Journal	Journal of virology
Volume	89
Issue number	22
DOIs	https://doi.org/10.1128/JVI.01989-15
State	Published - 2015

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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title = "Immune protection against virus challenge in aging mice is not affected by latent herpesviral infections",

abstract = "Latent herpesvirus infections alter immune homeostasis. To understand if this results in aging-related loss of immune protection against emerging infections, we challenged old mice carrying latent mouse cytomegalovirus (CMV), herpes simplex virus 1 (HSV-1), and/or murine gammaherpesvirus 68 (MHV-68) with influenza virus, West Nile virus (WNV), or vesicular stomatitis virus (VSV). We observed no increase in mortality or weight loss compared to results seen with herpesvirus-negative counterparts and a relative but not absolute reduction in CD8 responses to acute infections. Therefore, the presence of herpesviruses does not appear to increase susceptibility to emerging infections in aging patients.",

author = "Marandu, {Thomas F.} and Oduro, {Jennifer D.} and Lisa Borkner and Iryna Dekhtiarenko and Uhrlaub, {Jennifer L.} and Anja Drabig and Andrea Kr{\"o}ger and Janko Nikolich-Zugich and Luka Cicin-Sain",

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year = "2015",

doi = "10.1128/JVI.01989-15",

language = "English (US)",

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T1 - Immune protection against virus challenge in aging mice is not affected by latent herpesviral infections

AU - Marandu, Thomas F.

AU - Oduro, Jennifer D.

AU - Borkner, Lisa

AU - Dekhtiarenko, Iryna

AU - Uhrlaub, Jennifer L.

AU - Drabig, Anja

AU - Kröger, Andrea

AU - Nikolich-Zugich, Janko

AU - Cicin-Sain, Luka

PY - 2015

Y1 - 2015

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AB - Latent herpesvirus infections alter immune homeostasis. To understand if this results in aging-related loss of immune protection against emerging infections, we challenged old mice carrying latent mouse cytomegalovirus (CMV), herpes simplex virus 1 (HSV-1), and/or murine gammaherpesvirus 68 (MHV-68) with influenza virus, West Nile virus (WNV), or vesicular stomatitis virus (VSV). We observed no increase in mortality or weight loss compared to results seen with herpesvirus-negative counterparts and a relative but not absolute reduction in CD8 responses to acute infections. Therefore, the presence of herpesviruses does not appear to increase susceptibility to emerging infections in aging patients.

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Immune protection against virus challenge in aging mice is not affected by latent herpesviral infections

Abstract

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