Immune memory and aging: An infinite or finite resource?

Janko Nikolich-Žugich, Brian D. Rudd

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations


Recent developments in the field of immune memory research and the accumulating literature on age-related alterations in homeostasis, primary and memory T cell responses make it pertinent to address whether and how memory responses are affected by aging with regard to their generation, maintenance, and protective function. New knowledge of T cell repertoire maintenance over long periods of time, particularly when confronted with persistent pathogen challenge, is now enriched further by studies on whether recent immunological memory can 'overfill' and/or constrict prior memory responses. Along with studies on potentiation of memory responses by dietary/metabolic interventions and the recent advances on regulation of primary responses with aging, these findings provide a platform for new approaches to vaccination of older adults.

Original languageEnglish (US)
Pages (from-to)535-540
Number of pages6
JournalCurrent Opinion in Immunology
Issue number4
StatePublished - Aug 2010

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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