Imaging recognition of multidrug resistance in human breast tumors using 99mTc-labeled monocationic agents and a high-resolution stationary SPECT system

Zhonglin Liu; Gail D. Stevenson; Harrison H Barrett; George A. Kastis; Michael Bettan; Lars R. Furenlid; Donald W. Wilson; James M. Woolfenden

doi:10.1016/S0969-8051(03)00119-7

Imaging recognition of multidrug resistance in human breast tumors using ^99mTc-labeled monocationic agents and a high-resolution stationary SPECT system

Zhonglin Liu, Gail D. Stevenson, Harrison H Barrett, George A. Kastis, Michael Bettan, Lars R. Furenlid, Donald W. Wilson, James M. Woolfenden

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Imaging recognition of multidrug-resistance by ^99mTc-labeled sestamibi, tetrofosmin and furifosmin in mice bearing human breast tumors was evaluated using a high-resolution SPECT, FASTSPECT. Imaging results showed that the washout rates in drug-resistant MCF7/D40 tumors were significantly greater than that in drug-sensitive MCF7/S tumors. Furifosmin exhibited greater washout from both MCF7/S and MCF7/D40 than sestamibi, while tetrofosmin washout was greater than sestamibi in MCF7/D40 only. Feasibility of the monocationic agents for characterizing MDR expression was well clarified with FASTSPECT imaging.

Original language	English (US)
Pages (from-to)	53-65
Number of pages	13
Journal	Nuclear Medicine and Biology
Volume	31
Issue number	1
DOIs	https://doi.org/10.1016/S0969-8051(03)00119-7
State	Published - Jan 2004

Keywords

Breast tumor
High-resolution SPECT
Multidrug resistance
Tc- sestamibi
Tc-furifosmin
Tc-tetrofosmin

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

Access to Document

10.1016/S0969-8051(03)00119-7

Cite this

Liu, Z., Stevenson, G. D., Barrett, H. H., Kastis, G. A., Bettan, M., Furenlid, L. R., Wilson, D. W., & Woolfenden, J. M. (2004). Imaging recognition of multidrug resistance in human breast tumors using ^99mTc-labeled monocationic agents and a high-resolution stationary SPECT system. Nuclear Medicine and Biology, 31(1), 53-65. https://doi.org/10.1016/S0969-8051(03)00119-7

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title = "Imaging recognition of multidrug resistance in human breast tumors using 99mTc-labeled monocationic agents and a high-resolution stationary SPECT system",

abstract = "Imaging recognition of multidrug-resistance by 99mTc-labeled sestamibi, tetrofosmin and furifosmin in mice bearing human breast tumors was evaluated using a high-resolution SPECT, FASTSPECT. Imaging results showed that the washout rates in drug-resistant MCF7/D40 tumors were significantly greater than that in drug-sensitive MCF7/S tumors. Furifosmin exhibited greater washout from both MCF7/S and MCF7/D40 than sestamibi, while tetrofosmin washout was greater than sestamibi in MCF7/D40 only. Feasibility of the monocationic agents for characterizing MDR expression was well clarified with FASTSPECT imaging.",

keywords = "Breast tumor, High-resolution SPECT, Multidrug resistance, Tc- sestamibi, Tc-furifosmin, Tc-tetrofosmin",

author = "Zhonglin Liu and Stevenson, \{Gail D.\} and Barrett, \{Harrison H\} and Kastis, \{George A.\} and Michael Bettan and Furenlid, \{Lars R.\} and Wilson, \{Donald W.\} and Woolfenden, \{James M.\}",

note = "Funding Information: The authors wish to acknowledge Bethany Skovan, Gillian Paine and Henry Allan Toppin for assistance in establishing the animal model, and Brenda K Baggett for her expertise in preparing tissues for Western Blotting. We thank Amersham Health and Mallinckrodt Medical Inc. for kindly providing us with tetrofosmin (Myoview TM ) and furifosmin. This work was supported by NIH grants P41RR14304 and R24CA83148.",

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doi = "10.1016/S0969-8051(03)00119-7",

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AU - Kastis, George A.

AU - Bettan, Michael

AU - Furenlid, Lars R.

AU - Wilson, Donald W.

AU - Woolfenden, James M.

N1 - Funding Information: The authors wish to acknowledge Bethany Skovan, Gillian Paine and Henry Allan Toppin for assistance in establishing the animal model, and Brenda K Baggett for her expertise in preparing tissues for Western Blotting. We thank Amersham Health and Mallinckrodt Medical Inc. for kindly providing us with tetrofosmin (Myoview TM ) and furifosmin. This work was supported by NIH grants P41RR14304 and R24CA83148.

PY - 2004/1

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N2 - Imaging recognition of multidrug-resistance by 99mTc-labeled sestamibi, tetrofosmin and furifosmin in mice bearing human breast tumors was evaluated using a high-resolution SPECT, FASTSPECT. Imaging results showed that the washout rates in drug-resistant MCF7/D40 tumors were significantly greater than that in drug-sensitive MCF7/S tumors. Furifosmin exhibited greater washout from both MCF7/S and MCF7/D40 than sestamibi, while tetrofosmin washout was greater than sestamibi in MCF7/D40 only. Feasibility of the monocationic agents for characterizing MDR expression was well clarified with FASTSPECT imaging.

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KW - Tc-furifosmin

KW - Tc-tetrofosmin

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