IMAGING OF LYMPHATIC DYSPLASIA IN NOONAN SYNDROME: CASE STUDIES AND HISTORICAL ATLAS

T. Cox, C. Vance, S. Daley, C. Papendieck, H. McGregor, P. H. Kuo, Marlys H. Witte

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

To determine the historical use and utility of various lymphatic imaging modalities in Noonan syndrome (NS) patients, we performed a comprehensive literature review by collecting the published medical imaging of NS lymphatic dysplasias. We correlated imaging findings with clinical phenotypes and treatment. Our analysis of lymphatic imaging modalities provides an algorithmic approach to imaging and patient care across the spectrum of NS developmental defects. A total of 54 NS cases have been published since 1975. Using the observations reported in 15 reviewed publications, an association was made between disruptions in central lymphatic flow and poor clinical presentations/outcomes in NS patients.

Original languageEnglish (US)
Pages (from-to)23-40
Number of pages18
JournalLymphology
Volume54
Issue number1
DOIs
StatePublished - 2021

Keywords

  • Algorithm
  • Atlas
  • Imaging
  • Lymphangiography
  • Lymphatic imaging
  • Lymphatic vessel dysplasia
  • Noonan syndrome
  • Thoracic duct

ASJC Scopus subject areas

  • Immunology and Allergy
  • Hematology

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