Image reconstruction of optical tomographic data from a highly scattering medium

J. Lee; D. W. Wilson; H. H. Barrett; A. F. Gmitro

doi:10.1117/12.430909

Image reconstruction of optical tomographic data from a highly scattering medium

J. Lee, D. W. Wilson, H. H. Barrett, A. F. Gmitro

Research output: Contribution to journal › Conference article › peer-review

Abstract

Recently new technologies for detecting biomolecules have been developed and are opening a new era of medical imaging. Chemiluminescence and fluorescence are emerging as promising tools for these tasks. These molecules emit optical photons that can be observed outside the body. Unfortunately, they are heavily scattered and absorbed in biological tissue. This is an obstacle for determining a way of mapping an original source distribution. In order to overcome this obstacle, we suggest a new concept, Optical Emission Computed Tomography(OpECT) and test its feasibility with computer simulation.

Original language	English (US)
Pages (from-to)	792-799
Number of pages	8
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	4320
DOIs	https://doi.org/10.1117/12.430909
State	Published - 2001
Event	Medical Imaging 2001: Physics of Medical Imaging - San Diego, CA, United States Duration: Feb 18 2001 → Feb 20 2001

Keywords

Chemiluminescene
Fluorescence
ML-EM algorithm
Monte-Carlo Simulation
OpECT
Scattering Medium

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

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10.1117/12.430909

Cite this

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title = "Image reconstruction of optical tomographic data from a highly scattering medium",

abstract = "Recently new technologies for detecting biomolecules have been developed and are opening a new era of medical imaging. Chemiluminescence and fluorescence are emerging as promising tools for these tasks. These molecules emit optical photons that can be observed outside the body. Unfortunately, they are heavily scattered and absorbed in biological tissue. This is an obstacle for determining a way of mapping an original source distribution. In order to overcome this obstacle, we suggest a new concept, Optical Emission Computed Tomography(OpECT) and test its feasibility with computer simulation.",

keywords = "Chemiluminescene, Fluorescence, ML-EM algorithm, Monte-Carlo Simulation, OpECT, Scattering Medium",

author = "J. Lee and Wilson, {D. W.} and Barrett, {H. H.} and Gmitro, {A. F.}",

year = "2001",

doi = "10.1117/12.430909",

language = "English (US)",

volume = "4320",

pages = "792--799",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

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note = "Medical Imaging 2001: Physics of Medical Imaging ; Conference date: 18-02-2001 Through 20-02-2001",

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TY - JOUR

T1 - Image reconstruction of optical tomographic data from a highly scattering medium

AU - Lee, J.

AU - Wilson, D. W.

AU - Barrett, H. H.

AU - Gmitro, A. F.

PY - 2001

Y1 - 2001

N2 - Recently new technologies for detecting biomolecules have been developed and are opening a new era of medical imaging. Chemiluminescence and fluorescence are emerging as promising tools for these tasks. These molecules emit optical photons that can be observed outside the body. Unfortunately, they are heavily scattered and absorbed in biological tissue. This is an obstacle for determining a way of mapping an original source distribution. In order to overcome this obstacle, we suggest a new concept, Optical Emission Computed Tomography(OpECT) and test its feasibility with computer simulation.

AB - Recently new technologies for detecting biomolecules have been developed and are opening a new era of medical imaging. Chemiluminescence and fluorescence are emerging as promising tools for these tasks. These molecules emit optical photons that can be observed outside the body. Unfortunately, they are heavily scattered and absorbed in biological tissue. This is an obstacle for determining a way of mapping an original source distribution. In order to overcome this obstacle, we suggest a new concept, Optical Emission Computed Tomography(OpECT) and test its feasibility with computer simulation.

KW - Chemiluminescene

KW - Fluorescence

KW - ML-EM algorithm

KW - Monte-Carlo Simulation

KW - OpECT

KW - Scattering Medium

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DO - 10.1117/12.430909

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SN - 0277-786X

VL - 4320

SP - 792

EP - 799

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

T2 - Medical Imaging 2001: Physics of Medical Imaging

Y2 - 18 February 2001 through 20 February 2001

ER -

Image reconstruction of optical tomographic data from a highly scattering medium

Abstract

Keywords

ASJC Scopus subject areas

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