IL-17F deficiency inhibits small intestinal tumorigenesis in Apc Min/+ mice

Wook Jin Chae, Alfred L.M. Bothwell

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

IL-17 plays an important role in gut homeostasis. However, the role of IL-17F in intestinal tumorigenesis has not been addressed. Here we demonstrate that ablation of IL-17F significantly inhibits spontaneous intestinal tumorigenesis in the small intestine of Apc Min/+ mice. IL-17F ablation decreased IL-1β and Cox-2 expression as well as IL-17 receptor C (IL-17RC) expression, which were increased in tumors from Apc Min/+ mice. Lack of IL-17F did not reverse the splenomegaly but partially restored thymic atrophy, suggesting a local effect of IL-17F in the intestine. IL-17F deficient Apc Min/+ mice showed a significant decrease in immune cell infiltration in the lamina propria. Interestingly, the expression of IL-17A from CD4 T cells in the lamina propria remains unchanged in the absence of IL-17F. Collectively, our results suggest the proinflammatory and essential role of IL-17F to develop spontaneous intestinal tumorigenesis in Apc Min/+ mice in the presence of IL-17A.

Original languageEnglish (US)
Pages (from-to)31-36
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume414
Issue number1
DOIs
StatePublished - Oct 14 2011
Externally publishedYes

Keywords

  • IL-17
  • Inflammation
  • Tumor immunity

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'IL-17F deficiency inhibits small intestinal tumorigenesis in Apc Min/+ mice'. Together they form a unique fingerprint.

Cite this