IL-17 and intestinal tumorigenesis

Wook Jin Chae; Alfred L.M. Bothwell

doi:10.1016/j.ddmec.2011.11.001

IL-17 and intestinal tumorigenesis

Wook Jin Chae
, Alfred L.M. Bothwell

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

IL-17 is an important proinflammatory cytokine in autoimmune diseases. The constant presence of IL- 17 in the intestinal tract raises the possibility that it may be a critical enhancer of intestinal tumorigenesis. Yet the role of IL-17 in cancer development is controversial. Animal studies and clinical studies suggest that the role of IL-17 may be differential depending on type of cancer and tumor microenvironment. The role of IL- 17 in intestinal tumorigenesis is largely proinflammatory and likely affects Treg function. Thus, targeting IL- 17 in intestinal tumorigenesis may be an effective approach for treating cancer.

Original language	English (US)
Pages (from-to)	e79-e83
Journal	Drug Discovery Today: Disease Mechanisms
Volume	8
Issue number	3-4
DOIs	https://doi.org/10.1016/j.ddmec.2011.11.001
State	Published - 2011
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1016/j.ddmec.2011.11.001

Cite this

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title = "IL-17 and intestinal tumorigenesis",

abstract = "IL-17 is an important proinflammatory cytokine in autoimmune diseases. The constant presence of IL- 17 in the intestinal tract raises the possibility that it may be a critical enhancer of intestinal tumorigenesis. Yet the role of IL-17 in cancer development is controversial. Animal studies and clinical studies suggest that the role of IL-17 may be differential depending on type of cancer and tumor microenvironment. The role of IL- 17 in intestinal tumorigenesis is largely proinflammatory and likely affects Treg function. Thus, targeting IL- 17 in intestinal tumorigenesis may be an effective approach for treating cancer.",

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AU - Chae, Wook Jin

AU - Bothwell, Alfred L.M.

PY - 2011

Y1 - 2011

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AB - IL-17 is an important proinflammatory cytokine in autoimmune diseases. The constant presence of IL- 17 in the intestinal tract raises the possibility that it may be a critical enhancer of intestinal tumorigenesis. Yet the role of IL-17 in cancer development is controversial. Animal studies and clinical studies suggest that the role of IL-17 may be differential depending on type of cancer and tumor microenvironment. The role of IL- 17 in intestinal tumorigenesis is largely proinflammatory and likely affects Treg function. Thus, targeting IL- 17 in intestinal tumorigenesis may be an effective approach for treating cancer.

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UR - https://www.scopus.com/pages/publications/84860344672#tab=citedBy

U2 - 10.1016/j.ddmec.2011.11.001

DO - 10.1016/j.ddmec.2011.11.001

M3 - Review article

AN - SCOPUS:84860344672

SN - 1740-6765

VL - 8

SP - e79-e83

JO - Drug Discovery Today: Disease Mechanisms

JF - Drug Discovery Today: Disease Mechanisms

IS - 3-4

ER -

IL-17 and intestinal tumorigenesis

Abstract

ASJC Scopus subject areas

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