IL-17 and intestinal tumorigenesis

Wook Jin Chae, Alfred L.M. Bothwell

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


IL-17 is an important proinflammatory cytokine in autoimmune diseases. The constant presence of IL- 17 in the intestinal tract raises the possibility that it may be a critical enhancer of intestinal tumorigenesis. Yet the role of IL-17 in cancer development is controversial. Animal studies and clinical studies suggest that the role of IL-17 may be differential depending on type of cancer and tumor microenvironment. The role of IL- 17 in intestinal tumorigenesis is largely proinflammatory and likely affects Treg function. Thus, targeting IL- 17 in intestinal tumorigenesis may be an effective approach for treating cancer.

Original languageEnglish (US)
Pages (from-to)e79-e83
JournalDrug Discovery Today: Disease Mechanisms
Issue number3-4
StatePublished - 2011
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery


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