IL-17 and intestinal tumorigenesis

Wook Jin Chae; Alfred L.M. Bothwell

doi:10.1016/j.ddmec.2011.11.001

IL-17 and intestinal tumorigenesis

Wook Jin Chae, Alfred L.M. Bothwell

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

IL-17 is an important proinflammatory cytokine in autoimmune diseases. The constant presence of IL- 17 in the intestinal tract raises the possibility that it may be a critical enhancer of intestinal tumorigenesis. Yet the role of IL-17 in cancer development is controversial. Animal studies and clinical studies suggest that the role of IL-17 may be differential depending on type of cancer and tumor microenvironment. The role of IL- 17 in intestinal tumorigenesis is largely proinflammatory and likely affects Treg function. Thus, targeting IL- 17 in intestinal tumorigenesis may be an effective approach for treating cancer.

Original language	English (US)
Pages (from-to)	e79-e83
Journal	Drug Discovery Today: Disease Mechanisms
Volume	8
Issue number	3-4
DOIs	https://doi.org/10.1016/j.ddmec.2011.11.001
State	Published - 2011
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

Access to Document

10.1016/j.ddmec.2011.11.001

Cite this

@article{e40e7e0c83184f11a0d79b6fe607cfc9,

title = "IL-17 and intestinal tumorigenesis",

abstract = "IL-17 is an important proinflammatory cytokine in autoimmune diseases. The constant presence of IL- 17 in the intestinal tract raises the possibility that it may be a critical enhancer of intestinal tumorigenesis. Yet the role of IL-17 in cancer development is controversial. Animal studies and clinical studies suggest that the role of IL-17 may be differential depending on type of cancer and tumor microenvironment. The role of IL- 17 in intestinal tumorigenesis is largely proinflammatory and likely affects Treg function. Thus, targeting IL- 17 in intestinal tumorigenesis may be an effective approach for treating cancer.",

author = "Chae, {Wook Jin} and Bothwell, {Alfred L.M.}",

year = "2011",

doi = "10.1016/j.ddmec.2011.11.001",

language = "English (US)",

volume = "8",

pages = "e79--e83",

journal = "Drug Discovery Today: Disease Mechanisms",

issn = "1740-6765",

publisher = "Elsevier Ltd",

number = "3-4",

}

TY - JOUR

T1 - IL-17 and intestinal tumorigenesis

AU - Chae, Wook Jin

AU - Bothwell, Alfred L.M.

PY - 2011

Y1 - 2011

N2 - IL-17 is an important proinflammatory cytokine in autoimmune diseases. The constant presence of IL- 17 in the intestinal tract raises the possibility that it may be a critical enhancer of intestinal tumorigenesis. Yet the role of IL-17 in cancer development is controversial. Animal studies and clinical studies suggest that the role of IL-17 may be differential depending on type of cancer and tumor microenvironment. The role of IL- 17 in intestinal tumorigenesis is largely proinflammatory and likely affects Treg function. Thus, targeting IL- 17 in intestinal tumorigenesis may be an effective approach for treating cancer.

AB - IL-17 is an important proinflammatory cytokine in autoimmune diseases. The constant presence of IL- 17 in the intestinal tract raises the possibility that it may be a critical enhancer of intestinal tumorigenesis. Yet the role of IL-17 in cancer development is controversial. Animal studies and clinical studies suggest that the role of IL-17 may be differential depending on type of cancer and tumor microenvironment. The role of IL- 17 in intestinal tumorigenesis is largely proinflammatory and likely affects Treg function. Thus, targeting IL- 17 in intestinal tumorigenesis may be an effective approach for treating cancer.

UR - http://www.scopus.com/inward/record.url?scp=84860344672&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860344672&partnerID=8YFLogxK

U2 - 10.1016/j.ddmec.2011.11.001

DO - 10.1016/j.ddmec.2011.11.001

M3 - Review article

AN - SCOPUS:84860344672

SN - 1740-6765

VL - 8

SP - e79-e83

JO - Drug Discovery Today: Disease Mechanisms

JF - Drug Discovery Today: Disease Mechanisms

IS - 3-4

ER -

IL-17 and intestinal tumorigenesis

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this