Idiopathic Environmental Intolerances

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


The constellation of symptoms that has come to be known as multiple chemical sensitivities or idiopathic environmental intolerance is increasingly recognized, although the definition is elusive and its pathogenesis as a distinct entity is unconfirmed. The mechanisms that have been proposed include altered immune function, neurogenic inflammation, neurologic sensitization, and conditioned reflexes and genetic differences in drug metabolism enzymes or factors involved in the generation or response to oxidative stress. To date, no chemically related mechanism has been established.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Toxicology
Subtitle of host publicationThird Edition
Number of pages4
ISBN (Electronic)9780123864543
ISBN (Print)9780123864550
StatePublished - Jan 1 2014
Externally publishedYes


  • Idiopathic environmental intolerance
  • Kindling
  • Multiple chemical sensitivities
  • Neurogenic inflammation
  • Psychogenic
  • Somatoform

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Idiopathic Environmental Intolerances'. Together they form a unique fingerprint.

Cite this