Identification of populations likely to benefit from pharmacogenomic testing

Craig William Heise, Tyler Gallo, Steven C. Curry, Raymond L. Woosley

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Objectives Pharmacogenomic testing (PGX) implementation is rapidly expanding, including pre-emptive testing funded by health systems. PGX continues to develop an evidence base that it saves money and improves clinical outcomes. Identifying the potential impact of pre-emptive testing in specific populations may aid in the development of a business case. Methods We utilized a software tool that can evaluate patient drug lists and identified groups of patients most likely to benefit from implementation of a PGX testing program in a major medical system population. Results Medication lists were obtained for sixteen patient groups with a total of 82 613 patients. The percent of patients in each group with testing 'Recommended', 'Strongly recommended', or 'Required' ranged from 12.7% in the outpatient pediatric psychiatry group to 75.7% in the any adult inpatient age >50 years group. Some of the highest yield drugs identified were citalopram, simvastatin, escitalopram, metoprolol, clopidogrel, tramadol, and ondansetron. Conclusion We demonstrate a significant number of patients in each group may have benefit, but targeting certain ones for pre-emptive testing may result in the initial highest yield for a health system.

Original languageEnglish (US)
Pages (from-to)91-95
Number of pages5
JournalPharmacogenetics and Genomics
Volume30
Issue number5
DOIs
StatePublished - Jul 1 2020

Keywords

  • pharmacogenetics
  • pharmacogenomics
  • populations actionable
  • pre-emptive testing

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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