Abstract
The Microviridae consist of T = 1 single-stranded (+) DNA prokaryotic viruses. Due to genetic and biochemical tractability, φX174, the most widely known family member, was used to elucidate the mechanism of DNA replication and was the first completely sequenced genome. It is also a model system for structure and morphogenesis. The φX174 procapsid was the first viral assembly intermediate solved at atomic resolution, which made it a model system for protein structure and viral morphogenesis. Unlike double-stranded DNA bacteriophages, microviruses have no visible tails. However, a tail-like structure, or H-tube, emerges from the capsid upon infection, and currently serves as a paradigm for virally encoded DNA translocation conduits.
Original language | English (US) |
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Title of host publication | Encyclopedia of Virology |
Subtitle of host publication | Volume 1-5, Fourth Edition |
Publisher | Elsevier |
Pages | 10-20 |
Number of pages | 11 |
Volume | 1-5 |
ISBN (Electronic) | 9780128145166 |
DOIs | |
State | Published - Jan 1 2020 |
Keywords
- Bacteriophage φX174
- Coliphage
- DNA packaging
- DNA replication
- DNA translocation
- H-tube
- Microviridae
- Overlapping reading frames
- Penetration
- Procapsid
- Scaffolding protein
- Single-stranded DNA
- Viral morphogenesis
ASJC Scopus subject areas
- General Immunology and Microbiology