Hyperspectral Imaging of Renal Oxygenation (Near-Infrared Tissue Oximetry for Renal Ischemia)

It is recognized that after recovery from acute renal injury, the postischemic kidney is not fully restored to its preinjury state and some exhibit progressive deterioration in renal function. Researchers have attempted to elucidate the mechanisms by which renal ischemia and reperfusion injury lead to the development of chronic kidney disease. Histologically, kidney ischemia/reperfusion injury is characterized by tubular damage. Furthermore, when animal kidneys are microscopically examined in the postischemic recovery period, they demonstrate diminished renal microvasculature, interstitial fibrosis, tubular atrophy, and persistent inflammation. Microarray analyses have shed light on the role genes contribute to the long-term consequences of ischemic acute kidney injury.